ID   VME1_BRV1               Reviewed;         233 AA.
AC   O90305; Q3T8I9;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   07-OCT-2020, entry version 61.
DE   RecName: Full=Membrane protein;
DE            Short=M protein;
DE   AltName: Full=E1 glycoprotein;
DE   AltName: Full=Matrix glycoprotein;
DE   AltName: Full=Membrane glycoprotein;
GN   Name=M;
OS   Breda virus 1 (BRV-1).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Tornidovirineae; Tobaniviridae; Torovirinae; Torovirus;
OC   Renitovirus.
OX   NCBI_TaxID=360393;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9879765; DOI=10.1016/s0168-1702(98)00104-x;
RA   Duckmanton L.M., Tellier R., Liu P., Petric M.;
RT   "Bovine torovirus: sequencing of the structural genes and expression of the
RT   nucleocapsid protein of Breda virus.";
RL   Virus Res. 58:83-96(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16137782; DOI=10.1016/j.virusres.2005.07.005;
RA   Draker R., Roper R.L., Petric M., Tellier R.;
RT   "The complete sequence of the bovine torovirus genome.";
RL   Virus Res. 115:56-68(2006).
CC   -!- FUNCTION: Component of the viral envelope that plays a central role in
CC       virus morphogenesis and assembly via its interactions with other viral
CC       proteins. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with many viral proteins in infected cells.
CC       Interacts with envelope E protein in the budding compartment of the
CC       host cell, which is located between endoplasmic reticulum and the Golgi
CC       complex. Forms a complex with HE and S proteins. Interacts with
CC       nucleocapsid N protein. This interaction probably participates in the
CC       viral mRNA packaging into the virus (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Host Golgi apparatus membrane
CC       {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the torovirinae M protein family. {ECO:0000305}.
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DR   EMBL; AF076621; AAD03841.1; -; Genomic_RNA.
DR   EMBL; AY427798; AAS17960.1; -; Genomic_RNA.
DR   RefSeq; YP_337908.1; NC_007447.1.
DR   SMR; O90305; -.
DR   GeneID; 3707769; -.
DR   KEGG; vg:3707769; -.
DR   Proteomes; UP000000355; Genome.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR   InterPro; IPR024251; M_Torovirus.
DR   Pfam; PF10943; DUF2632; 1.
PE   3: Inferred from homology;
KW   Host Golgi apparatus; Host membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Viral envelope protein;
KW   Viral matrix protein; Virion.
FT   CHAIN           1..233
FT                   /note="Membrane protein"
FT                   /id="PRO_0000283930"
FT   TOPO_DOM        1..31
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..69
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        91..93
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..233
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255"
FT   VARIANT         105
FT                   /note="G -> V"
FT   VARIANT         113
FT                   /note="S -> F"
FT   VARIANT         121
FT                   /note="K -> R"
FT   VARIANT         223
FT                   /note="E -> D"
SQ   SEQUENCE   233 AA;  26294 MW;  512F2B8434434A14 CRC64;
     MFETNYWPFP DQAPNPFNAQ VEQLSATENV YIFLTTLFGI LQLVYVIFKL LCTMFPALHW
     SPIWRGLENF WLFLSLASLA IAYWWLPSMT FTGYWALTII ATILGLIMLI MMSVKFVSFV
     KLFYRTGSFA IAIRGPIVLV ALDVTIKLHC TPFAILVKEV GNIFYLSEYC NKPLTAAQVA
     ALRICVGGQW FAYTRSTTTS AAKVAAANST AKYHLFVLQG VAEYTQLSSV KFE