VME1_CVBM
ID VME1_CVBM Reviewed; 230 AA.
AC P69704; P10526; P36359;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 29-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04202};
DE Short=M protein {ECO:0000255|HAMAP-Rule:MF_04202};
DE AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202};
DE AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202};
DE AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202};
GN Name=M {ECO:0000255|HAMAP-Rule:MF_04202}; ORFNames=6;
OS Bovine coronavirus (strain Mebus) (BCoV) (BCV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Betacoronavirus; Embecovirus.
OX NCBI_TaxID=11132;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=3029965; DOI=10.1016/0042-6822(87)90312-6;
RA Lapps W.E., Hogue B.G., Brian D.A.;
RT "Sequence analysis of the bovine coronavirus nucleocapsid and matrix
RT protein genes.";
RL Virology 157:47-57(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=3434434; DOI=10.1007/978-1-4684-1280-2_14;
RA Lapps W.E., Hogue B.G., Brian D.A.;
RT "Deduced amino acid sequence and potential O-glycosylation sites for the
RT bovine coronavirus matrix protein.";
RL Adv. Exp. Med. Biol. 218:123-129(1987).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=7966615; DOI=10.1128/jvi.68.12.8223-8231.1994;
RA Chang R.Y., Hofmann M.A., Sethna P.B., Brian D.A.;
RT "A cis-acting function for the coronavirus leader in defective interfering
RT RNA replication.";
RL J. Virol. 68:8223-8231(1994).
RN [4]
RP INTERACTION WITH HE AND S.
RX PubMed=9371586; DOI=10.1128/jvi.71.12.9278-9284.1997;
RA Nguyen V.-P., Hogue B.G.;
RT "Protein interactions during coronavirus assembly.";
RL J. Virol. 71:9278-9284(1997).
CC -!- FUNCTION: Component of the viral envelope that plays a central role in
CC virus morphogenesis and assembly via its interactions with other viral
CC proteins. {ECO:0000255|HAMAP-Rule:MF_04202, ECO:0000255|PROSITE-
CC ProRule:PRU01275}.
CC -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Forms a complex with HE and S
CC proteins. Interacts with nucleocapsid N protein. This interaction
CC probably participates in RNA packaging into the virus.
CC {ECO:0000255|HAMAP-Rule:MF_04202, ECO:0000255|PROSITE-ProRule:PRU01275,
CC ECO:0000269|PubMed:9371586}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC Rule:MF_04202}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04202}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04202}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04202}. Note=Largely embedded in the lipid bilayer.
CC {ECO:0000255|HAMAP-Rule:MF_04202}.
CC -!- SIMILARITY: Belongs to the betacoronaviruses M protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04202}.
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DR EMBL; M27474; AAA79959.1; -; Genomic_RNA.
DR EMBL; U00735; AAK29779.2; -; Genomic_RNA.
DR PIR; A26347; VGIHBC.
DR SMR; P69704; -.
DR Proteomes; UP000007554; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule.
DR CDD; cd21568; HCoV-like_M; 1.
DR HAMAP; MF_04202; BETA_CORONA_M; 1.
DR InterPro; IPR002574; M_CoV.
DR InterPro; IPR044362; M_HCoV-like.
DR Pfam; PF01635; CoV_M; 1.
DR PROSITE; PS51927; COV_M; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Host Golgi apparatus; Host membrane; Host-virus interaction;
KW Membrane; Transmembrane; Transmembrane helix; Viral envelope protein;
KW Viral immunoevasion; Viral matrix protein; Virion.
FT CHAIN 1..230
FT /note="Membrane protein"
FT /id="PRO_0000106030"
FT TOPO_DOM 1..24
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT TOPO_DOM 46..55
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT TOPO_DOM 77..84
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT TOPO_DOM 106..228
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
SQ SEQUENCE 230 AA; 26372 MW; 6A7EA77313E01730 CRC64;
MSSVTTPAPV YTWTADEAIK FLKEWNFSLG IILLFITIIL QFGYTSRSMF VYVIKMIILW
LMWPLTIILT IFNCVYALNN VYLGFSIVFT IVAIIMWIVY FVNSIRLFIR TGSWWSFNPE
TNNLMCIDMK GRMYVRPIIE DYHTLTVTII RGHLYMQGIK LGTGYSLSDL PAYVTVAKVS
HLLTYKRGFL DKIGDTSGFA VYVKSKVGNY RLPSTQKGSG MDTALLRNNI
