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VME1_CVCAI
ID   VME1_CVCAI              Reviewed;         262 AA.
AC   P36299;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   07-APR-2021, entry version 90.
DE   RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04201};
DE            Short=M protein {ECO:0000255|HAMAP-Rule:MF_04201};
DE   AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
DE   AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
DE   AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
GN   Name=M {ECO:0000255|HAMAP-Rule:MF_04201};
OS   Canine coronavirus (strain Insavc-1) (CCoV) (Canine enteric coronavirus).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Alphacoronavirus; Tegacovirus.
OX   NCBI_TaxID=36391;
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1431811; DOI=10.1099/0022-1317-73-11-2849;
RA   Horsburgh B.C., Brierley I., Brown T.D.K.;
RT   "Analysis of a 9.6 kb sequence from the 3' end of canine coronavirus
RT   genomic RNA.";
RL   J. Gen. Virol. 73:2849-2862(1992).
CC   -!- FUNCTION: Component of the viral envelope that plays a central role in
CC       virus morphogenesis and assembly via its interactions with other viral
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_04201, ECO:0000255|PROSITE-
CC       ProRule:PRU01275}.
CC   -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Forms a complex with HE and S
CC       proteins. Interacts with nucleocapsid N protein. This interaction
CC       probably participates in RNA packaging into the virus.
CC       {ECO:0000255|HAMAP-Rule:MF_04201, ECO:0000255|PROSITE-
CC       ProRule:PRU01275}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04201}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04201}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04201}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04201}. Note=Largely embedded in the lipid bilayer.
CC       {ECO:0000255|HAMAP-Rule:MF_04201}.
CC   -!- SIMILARITY: Belongs to the alphacoronaviruses M protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04201}.
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DR   EMBL; D13096; BAA02413.1; -; Genomic_RNA.
DR   PIR; JQ1724; JQ1724.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule.
DR   CDD; cd21564; alphaCoV_M; 1.
DR   HAMAP; MF_04201; ALPHA_CORONA_M; 1.
DR   InterPro; IPR042551; ALPHA_CORONA_M.
DR   InterPro; IPR002574; M_CoV.
DR   Pfam; PF01635; CoV_M; 1.
DR   PROSITE; PS51927; COV_M; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Viral matrix protein; Virion.
FT   CHAIN           1..262
FT                   /note="Membrane protein"
FT                   /id="PRO_0000037153"
FT   TOPO_DOM        19..47
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TOPO_DOM        69..77
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TOPO_DOM        99..112
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TOPO_DOM        134..262
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   REGION          237..252
FT                   /note="Interaction with N protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
SQ   SEQUENCE   262 AA;  29509 MW;  35C6D45DC6A474F6 CRC64;
     MKKILFLLAC AIACVYGERY CAMTESSTSC RNSTAGNCAS CFETGDLIWH LANWNFSWSV
     ILIIFITVLQ YGRPQFSWFV CGIKMLIMWL LWPIVLALTI FNAYLEYRVS RYVMFGFSVA
     GATVTFILWI MYFVRSIQLY RRTKSWWSFN PETSAILCVS ALGRSYVLPL EGVPTGVTLT
     LLSGNLCAEG FKIAGGMNID NLPKYVMVAL PVRTIVYTLV GKKLKASSAT GWAYYVKSKA
     GDYSTDARTD NLSEHEKLLH MV
 
 
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