VME1_CVHNL
ID VME1_CVHNL Reviewed; 226 AA.
AC Q6Q1R9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 02-JUN-2021, entry version 66.
DE RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04201};
DE Short=M protein {ECO:0000255|HAMAP-Rule:MF_04201};
DE AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
DE AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
DE AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
GN Name=M {ECO:0000255|HAMAP-Rule:MF_04201}; ORFNames=5;
OS Human coronavirus NL63 (HCoV-NL63).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Alphacoronavirus; Setracovirus.
OX NCBI_TaxID=277944;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate Amsterdam I;
RX PubMed=15034574; DOI=10.1038/nm1024;
RA Van Der Hoek L., Pyrc K., Jebbink M.F., Vermeulen-Oost W., Berkhout R.J.,
RA Wolthers K.C., Wertheim-Van Dillen P.M., Kaandorp J., Spaargaren J.,
RA Berkhout B.;
RT "Identification of a new human coronavirus.";
RL Nat. Med. 10:368-373(2004).
CC -!- FUNCTION: Component of the viral envelope that plays a central role in
CC virus morphogenesis and assembly via its interactions with other viral
CC proteins. {ECO:0000255|HAMAP-Rule:MF_04201, ECO:0000255|PROSITE-
CC ProRule:PRU01275}.
CC -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Forms a complex with HE and S
CC proteins. Interacts with nucleocapsid N protein. This interaction
CC probably participates in RNA packaging into the virus.
CC {ECO:0000255|HAMAP-Rule:MF_04201, ECO:0000255|PROSITE-
CC ProRule:PRU01275}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC Rule:MF_04201}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04201}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04201}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04201}. Note=Largely embedded in the lipid bilayer.
CC {ECO:0000255|HAMAP-Rule:MF_04201}.
CC -!- SIMILARITY: Belongs to the alphacoronaviruses M protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04201}.
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DR EMBL; AY567487; AAS58180.1; -; Genomic_RNA.
DR RefSeq; YP_003770.1; NC_005831.2.
DR DNASU; 2943503; -.
DR GeneID; 2943503; -.
DR KEGG; vg:2943503; -.
DR Proteomes; UP000008573; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule.
DR CDD; cd21564; alphaCoV_M; 1.
DR HAMAP; MF_04201; ALPHA_CORONA_M; 1.
DR InterPro; IPR042551; ALPHA_CORONA_M.
DR InterPro; IPR002574; M_CoV.
DR Pfam; PF01635; CoV_M; 1.
DR PROSITE; PS51927; COV_M; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW Transmembrane helix; Viral envelope protein; Viral matrix protein; Virion.
FT CHAIN 1..226
FT /note="Membrane protein"
FT /id="PRO_0000283931"
FT TOPO_DOM 1..11
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TOPO_DOM 33..41
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TOPO_DOM 63..75
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TOPO_DOM 97..226
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT REGION 200..216
FT /note="Interaction with N protein"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
SQ SEQUENCE 226 AA; 25929 MW; B04F630452B3C6EE CRC64;
MSNSSVPLLE VYVHLRNWNF SWNLILTLFI VVLQYGHYKY SRLLYGLKMS VLWCLWPLVL
ALSIFDCFVN FNVDWVFFGF SILMSIITLC LWVMYFVNSF RLWRRVKTFW AFNPETNAII
SLQVYGHNYY LPVMAAPTGV TLTLLSGVLL VDGHKIATRV QVGQLPKYVI VATPSTTIVC
DRVGRSVNET SQTGWAFYVR AKHGDFSGVA SQEGVLSERE KLLHLI
