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VME1_CVHOC
ID   VME1_CVHOC              Reviewed;         230 AA.
AC   Q01455; Q6TNF6;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04202};
DE            Short=M protein {ECO:0000255|HAMAP-Rule:MF_04202};
DE   AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202};
DE   AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202};
DE   AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04202};
GN   Name=M {ECO:0000255|HAMAP-Rule:MF_04202}; ORFNames=6;
OS   Human coronavirus OC43 (HCoV-OC43).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Embecovirus.
OX   NCBI_TaxID=31631;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA], AND GLYCOSYLATION AT SER-2; SER-3;
RP   THR-5; THR-6; THR-14 AND SER-28.
RX   PubMed=1402806; DOI=10.1099/0022-1317-73-10-2731;
RA   Mounir S., Talbot P.J.;
RT   "Sequence analysis of the membrane protein gene of human coronavirus OC43
RT   and evidence for O-glycosylation.";
RL   J. Gen. Virol. 73:2731-2736(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate ATCC VR-759, and Isolate clinical OC43-Paris;
RX   PubMed=15280490; DOI=10.1128/jvi.78.16.8824-8834.2004;
RA   St Jean J.R., Jacomy H., Desforges M., Vabret A., Freymuth F., Talbot P.J.;
RT   "Human respiratory coronavirus OC43: genetic stability and neuroinvasion.";
RL   J. Virol. 78:8824-8834(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate ATCC VR-759;
RX   PubMed=15650185; DOI=10.1128/jvi.79.3.1595-1604.2005;
RA   Vijgen L., Keyaerts E., Moes E., Thoelen I., Wollants E., Lemey P.,
RA   Vandamme A.M., Van Ranst M.;
RT   "Complete genomic sequence of human coronavirus OC43: molecular clock
RT   analysis suggests a relatively recent zoonotic coronavirus transmission
RT   event.";
RL   J. Virol. 79:1595-1604(2005).
CC   -!- FUNCTION: Component of the viral envelope that plays a central role in
CC       virus morphogenesis and assembly via its interactions with other viral
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_04202, ECO:0000255|PROSITE-
CC       ProRule:PRU01275}.
CC   -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Forms a complex with HE and S
CC       proteins. Interacts with nucleocapsid N protein. This interaction
CC       probably participates in RNA packaging into the virus.
CC       {ECO:0000255|HAMAP-Rule:MF_04202, ECO:0000255|PROSITE-
CC       ProRule:PRU01275}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04202}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04202}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04202}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04202}. Note=Largely embedded in the lipid bilayer.
CC       {ECO:0000255|HAMAP-Rule:MF_04202}.
CC   -!- PTM: O-linked glycans consist of Gal-GalNAc disaccharides which are
CC       modified with up to 2 sialic acid residues.
CC       {ECO:0000269|PubMed:1402806}.
CC   -!- SIMILARITY: Belongs to the betacoronaviruses M protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04202}.
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DR   EMBL; M93390; AAA45462.1; -; Genomic_RNA.
DR   EMBL; AY585229; AAT84365.1; -; Genomic_RNA.
DR   EMBL; AY585228; AAT84357.1; -; Genomic_RNA.
DR   EMBL; AY391777; AAR01018.1; -; Genomic_RNA.
DR   PIR; JQ1749; JQ1749.
DR   iPTMnet; Q01455; -.
DR   Proteomes; UP000007552; Genome.
DR   Proteomes; UP000100580; Genome.
DR   Proteomes; UP000180344; Genome.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule.
DR   CDD; cd21568; HCoV-like_M; 1.
DR   HAMAP; MF_04202; BETA_CORONA_M; 1.
DR   InterPro; IPR002574; M_CoV.
DR   InterPro; IPR044362; M_HCoV-like.
DR   Pfam; PF01635; CoV_M; 1.
DR   PROSITE; PS51927; COV_M; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Host Golgi apparatus; Host membrane; Host-virus interaction;
KW   Membrane; Transmembrane; Transmembrane helix; Viral envelope protein;
KW   Viral immunoevasion; Viral matrix protein; Virion.
FT   CHAIN           1..230
FT                   /note="Membrane protein"
FT                   /id="PRO_0000106033"
FT   TOPO_DOM        1..24
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT   TOPO_DOM        46..55
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT   TOPO_DOM        77..84
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT   TOPO_DOM        106..228
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04202"
FT   CARBOHYD        2
FT                   /note="O-linked (GalNAc...) serine; by host"
FT                   /evidence="ECO:0000269|PubMed:1402806"
FT   CARBOHYD        3
FT                   /note="O-linked (GalNAc...) serine; by host"
FT                   /evidence="ECO:0000269|PubMed:1402806"
FT   CARBOHYD        5
FT                   /note="O-linked (GalNAc...) threonine; by host"
FT                   /evidence="ECO:0000269|PubMed:1402806"
FT   CARBOHYD        6
FT                   /note="O-linked (GalNAc...) threonine; by host"
FT                   /evidence="ECO:0000269|PubMed:1402806"
FT   CARBOHYD        14
FT                   /note="O-linked (GalNAc...) threonine; by host"
FT                   /evidence="ECO:0000269|PubMed:1402806"
FT   CARBOHYD        28
FT                   /note="O-linked (GalNAc...) serine; by host"
FT                   /evidence="ECO:0000269|PubMed:1402806"
FT   VARIANT         167
FT                   /note="W -> L (in strain: Isolate ATCC VR-759 and Isolate
FT                   clinical OC43-Paris)"
SQ   SEQUENCE   230 AA;  26418 MW;  4E5C6E9400FB7C18 CRC64;
     MSSKTTPAPV YIWTADEAIK FLKEWNFSLG IILLFITIIL QFGYTSRSMF VYVIKMIILW
     LMWPLTIILT IFNCVYALNN VYLGLSIVFT IVAIIMWIVY FVNSIRLFIR TGSFWSFNPE
     TNNLMCIDMK GTMYVRPIIE DYHTLTVTII RGHLYIQGIK LGTGYSWADL PAYMTVAKVT
     HLCTYKRGFL DRISDTSGFA VYVKSKVGNY RLPSTQKGSG MDTALLRNNI
 
 
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