VME1_IBVBC
ID VME1_IBVBC Reviewed; 225 AA.
AC P69602; P04327;
DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-1987, sequence version 1.
DT 07-APR-2021, entry version 59.
DE RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04203};
DE Short=M protein {ECO:0000255|HAMAP-Rule:MF_04203};
DE AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
DE AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
DE AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
GN Name=M {ECO:0000255|HAMAP-Rule:MF_04203};
OS Avian infectious bronchitis virus (strain Beaudette CK) (IBV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Gammacoronavirus; Igacovirus.
OX NCBI_TaxID=160235;
OH NCBI_TaxID=9031; Gallus gallus (Chicken).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=11711626; DOI=10.1128/jvi.75.24.12359-12369.2001;
RA Casais R., Thiel V., Siddell S.G., Cavanagh D., Britton P.;
RT "Reverse genetics system for the avian coronavirus infectious bronchitis
RT virus.";
RL J. Virol. 75:12359-12369(2001).
CC -!- FUNCTION: Component of the viral envelope that plays a central role in
CC virus morphogenesis and assembly via its interactions with other viral
CC proteins. {ECO:0000255|HAMAP-Rule:MF_04203, ECO:0000255|PROSITE-
CC ProRule:PRU01275}.
CC -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Forms a complex with HE and S
CC proteins. Interacts with nucleocapsid N protein. This interaction
CC probably participates in RNA packaging into the virus.
CC {ECO:0000255|HAMAP-Rule:MF_04203, ECO:0000255|PROSITE-
CC ProRule:PRU01275}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC Rule:MF_04203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04203}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04203}. Note=Largely embedded in the lipid bilayer.
CC {ECO:0000255|HAMAP-Rule:MF_04203}.
CC -!- SIMILARITY: Belongs to the gammacoronaviruses M protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04203}.
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DR EMBL; AJ311317; CAC39118.1; -; Genomic_RNA.
DR Proteomes; UP000114388; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule.
DR CDD; cd21566; gammaCoV_M; 1.
DR HAMAP; MF_04203; GAMMA_CORONA_M; 1.
DR InterPro; IPR042550; GAMMA_CORONA_M.
DR InterPro; IPR002574; M_CoV.
DR Pfam; PF01635; CoV_M; 1.
DR PROSITE; PS51927; COV_M; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW Transmembrane helix; Viral envelope protein; Viral matrix protein; Virion.
FT CHAIN 1..225
FT /note="Membrane protein"
FT /id="PRO_0000106048"
FT TOPO_DOM 1..20
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TOPO_DOM 42..51
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TOPO_DOM 73..77
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TOPO_DOM 99..225
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
SQ SEQUENCE 225 AA; 25476 MW; D5AE8685CF78220D CRC64;
MPNETNCTLD FEQSVQLFKE YNLFITAFLL FLTIILQYGY ATRSKVIYTL KMIVLWCFWP
LNIAVGVISC TYPPNTGGLV AAIILTVFAC LSFVGYWIQS IRLFKRCRSW WSFNPESNAV
GSILLTNGQQ CNFAIESVPM VLSPIIKNGV LYCEGQWLAK CEPDHLPKDI FVCTPDRRNI
YRMVQKYTGD QSGNKKRFAT FVYAKQSVDT GELESVATGG SSLYT