VME1_IBVDE
ID VME1_IBVDE Reviewed; 225 AA.
AC Q9J3N8; Q9J3N9; Q9J3P0; Q9J3P1; Q9J3P2; Q9J3P3; Q9J4B3;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2003, sequence version 2.
DT 29-SEP-2021, entry version 78.
DE RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04203};
DE Short=M protein {ECO:0000255|HAMAP-Rule:MF_04203};
DE AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
DE AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
DE AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
GN Name=M {ECO:0000255|HAMAP-Rule:MF_04203};
OS Avian infectious bronchitis virus (strain DE072) (IBV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Gammacoronavirus; Igacovirus.
OX NCBI_TaxID=233265;
OH NCBI_TaxID=9031; Gallus gallus (Chicken).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate AR/6386/97, Isolate GA/5381/99, Isolate GA/5658/99,
RC Isolate IL/2831/98, Isolate KS/5425/99, and Isolate MN/6370/97;
RX PubMed=11087096; DOI=10.1007/s007050070044;
RA Lee C.-W., Jackwood M.W.;
RT "Evidence of genetic diversity generated by recombination among avian
RT coronavirus IBV.";
RL Arch. Virol. 145:2135-2148(2000).
CC -!- FUNCTION: Component of the viral envelope that plays a central role in
CC virus morphogenesis and assembly via its interactions with other viral
CC proteins. {ECO:0000255|HAMAP-Rule:MF_04203, ECO:0000255|PROSITE-
CC ProRule:PRU01275}.
CC -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Forms a complex with HE and S
CC proteins. Interacts with nucleocapsid N protein. This interaction
CC probably participates in RNA packaging into the virus.
CC {ECO:0000255|HAMAP-Rule:MF_04203, ECO:0000255|PROSITE-
CC ProRule:PRU01275}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC Rule:MF_04203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04203}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04203}. Note=Largely embedded in the lipid bilayer.
CC {ECO:0000255|HAMAP-Rule:MF_04203}.
CC -!- SIMILARITY: Belongs to the gammacoronaviruses M protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04203}.
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DR EMBL; AF202999; AAF69113.1; -; Genomic_RNA.
DR EMBL; AF206266; AAF67556.1; -; Genomic_RNA.
DR EMBL; AF206267; AAF67557.1; -; Genomic_RNA.
DR EMBL; AF206268; AAF67558.1; -; Genomic_RNA.
DR EMBL; AF206269; AAF67559.1; -; Genomic_RNA.
DR EMBL; AF206270; AAF67560.1; -; Genomic_RNA.
DR EMBL; AF206271; AAF67561.1; -; Genomic_RNA.
DR TCDB; 1.A.117.1.7; the coronavirus membrane matrix-protein (m-protein) family.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule.
DR CDD; cd21566; gammaCoV_M; 1.
DR HAMAP; MF_04203; GAMMA_CORONA_M; 1.
DR InterPro; IPR042550; GAMMA_CORONA_M.
DR InterPro; IPR002574; M_CoV.
DR Pfam; PF01635; CoV_M; 1.
DR PROSITE; PS51927; COV_M; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW Transmembrane helix; Viral envelope protein; Viral matrix protein; Virion.
FT CHAIN 1..225
FT /note="Membrane protein"
FT /id="PRO_0000106054"
FT TOPO_DOM 1..20
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TOPO_DOM 42..51
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TOPO_DOM 73..77
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT TOPO_DOM 99..225
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT VARIANT 2..4
FT /note="SNE -> DNV (in strain: Isolate MN/6370/97)"
FT VARIANT 2
FT /note="S -> A (in strain: Isolate AR/6386/97)"
FT VARIANT 11..12
FT /note="FE -> LQ (in strain: Isolate MN/6370/97)"
FT VARIANT 15..16
FT /note="VE -> IL (in strain: Isolate MN/6370/97)"
FT VARIANT 16
FT /note="E -> K (in strain: Isolate IL/2831/98)"
FT VARIANT 17
FT /note="L -> F (in strain: Isolate AR/6386/97)"
FT VARIANT 34
FT /note="I -> M (in strain: Isolate GA/5381/99)"
FT VARIANT 35
FT /note="I -> L (in strain: Isolate IL/2831/98 and Isolate
FT MN/6370/97)"
FT VARIANT 44..49
FT /note="SKFIYI -> NRLIYA (in strain: Isolate IL/2831/98)"
FT VARIANT 44
FT /note="S -> I (in strain: Isolate AR/6386/97)"
FT VARIANT 45
FT /note="K -> R (in strain: Isolate MN/6370/97)"
FT VARIANT 46
FT /note="F -> I (in strain: Isolate GA/5381/99)"
FT VARIANT 49..50
FT /note="IL -> VM (in strain: Isolate MN/6370/97)"
FT VARIANT 53
FT /note="I -> V (in strain: Isolate AR/6386/97, Isolate GA/
FT 5381/99, Isolate GA/5658/99 and Isolate KS/5425/99)"
FT VARIANT 62
FT /note="N -> I (in strain: Isolate KS/5425/99)"
FT VARIANT 76
FT /note="T -> I (in strain: Isolate GA/5381/99)"
FT VARIANT 101
FT /note="I -> C (in strain: Isolate IL/2831/98)"
FT VARIANT 108
FT /note="R -> K (in strain: Isolate IL/2831/98)"
FT VARIANT 112
FT /note="S -> A (in strain: Isolate MN/6370/97)"
FT VARIANT 132
FT /note="N -> S (in strain: Isolate MN/6370/97)"
FT VARIANT 140
FT /note="T -> M (in strain: Isolate AR/6386/97, Isolate IL/
FT 2831/98, Isolate GA/5381/99, Isolate GA/5658/99, Isolate
FT KS/5425/99 and Isolate MN/6370/97)"
FT VARIANT 150
FT /note="F -> A (in strain: Isolate GA/5381/99)"
FT VARIANT 150
FT /note="F -> V (in strain: Isolate AR/6386/97, Isolate GA/
FT 5658/99, Isolate IL/2831/98, Isolate KS/5425/99 and Isolate
FT MN/6370/97)"
FT VARIANT 180
FT /note="I -> T (in strain: Isolate IL/2831/98)"
SQ SEQUENCE 225 AA; 25557 MW; 082246BAAD20D74C CRC64;
MSNETNCTLD FEQSVELFKE YNLFITAFLL FLTIILQYGY ATRSKFIYIL KMIVLWCFWP
LNIAVGVISC IYPPNTGGLV AAIILTVFAC LSFVGYWIQS IRLFKRCRSW WSFNPESNAV
GSILLTNGQQ CNFAIESVPT VLSPIIKNGF LYCEGQWLAK CEPDHLPKDI FVCTPDRRNI
YRMVQKYTGD QSGNKKRFAT FVYAKQSVDT GELESVATGG SSLYT
