ID   VME1_IBVG               Reviewed;         223 AA.
AC   Q910E2;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   07-APR-2021, entry version 72.
DE   RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04203};
DE            Short=M protein {ECO:0000255|HAMAP-Rule:MF_04203};
DE   AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
DE   AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
DE   AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
GN   Name=M {ECO:0000255|HAMAP-Rule:MF_04203};
OS   Avian infectious bronchitis virus (strain Gray) (IBV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Gammacoronavirus; Igacovirus.
OX   NCBI_TaxID=31624;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11087096; DOI=10.1007/s007050070044;
RA   Lee C.-W., Jackwood M.W.;
RT   "Evidence of genetic diversity generated by recombination among avian
RT   coronavirus IBV.";
RL   Arch. Virol. 145:2135-2148(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Brooks J.E., Rainer A.C., Parr R.L., Collisson E.W.;
RT   "Comparisons of the membrane protein genes of various strains of avian
RT   infectious bronchitis virus.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the viral envelope that plays a central role in
CC       virus morphogenesis and assembly via its interactions with other viral
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_04203, ECO:0000255|PROSITE-
CC       ProRule:PRU01275}.
CC   -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Forms a complex with HE and S
CC       proteins. Interacts with nucleocapsid N protein. This interaction
CC       probably participates in RNA packaging into the virus.
CC       {ECO:0000255|HAMAP-Rule:MF_04203, ECO:0000255|PROSITE-
CC       ProRule:PRU01275}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04203}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04203}. Note=Largely embedded in the lipid bilayer.
CC       {ECO:0000255|HAMAP-Rule:MF_04203}.
CC   -!- SIMILARITY: Belongs to the gammacoronaviruses M protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04203}.
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DR   EMBL; AF363607; AAK50034.1; -; Genomic_RNA.
DR   EMBL; AF286180; AAK83026.1; -; mRNA.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule.
DR   CDD; cd21566; gammaCoV_M; 1.
DR   HAMAP; MF_04203; GAMMA_CORONA_M; 1.
DR   InterPro; IPR042550; GAMMA_CORONA_M.
DR   InterPro; IPR002574; M_CoV.
DR   Pfam; PF01635; CoV_M; 1.
DR   PROSITE; PS51927; COV_M; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Viral matrix protein; Virion.
FT   CHAIN           1..223
FT                   /note="Membrane protein"
FT                   /id="PRO_0000106055"
FT   TOPO_DOM        1..18
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TOPO_DOM        40..49
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TOPO_DOM        71..75
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TOPO_DOM        97..223
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
SQ   SEQUENCE   223 AA;  25171 MW;  E9EFA9FD6DE8CF5E CRC64;
     MAENCTLDSE QAVLLFKEYN LFITAFLLFL TILLQYGYAT RSRTIYILKM IVLWCFWPLN
     IAVGVISCIY PPNTGGLVAA IILTVFACLS FVGYWIQSCR LFKRCRSWWS FNPESNAVGS
     ILLTNGQQCN FAIESVPMVL APIIKNGVLY CEGQWLAKCE PDHLPKDIFV CTPDRRNIYR
     MVQKYTGDQS GNKKRFATFV YAKQSVDTGE LESVATGGSS LYT