ID   VME1_IBVH5              Reviewed;         225 AA.
AC   P69607; Q91GB7; Q99AS5;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   07-APR-2021, entry version 56.
DE   RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04203};
DE            Short=M protein {ECO:0000255|HAMAP-Rule:MF_04203};
DE   AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
DE   AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
DE   AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04203};
GN   Name=M {ECO:0000255|HAMAP-Rule:MF_04203};
OS   Avian infectious bronchitis virus (strain H52) (IBV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Gammacoronavirus; Igacovirus.
OX   NCBI_TaxID=231425;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=H52-GD;
RA   Cao W.S., Liao M., Ren T., Xin C.A.;
RT   "Sequence analysis of matrix gene of several strains of avian infectious
RT   bronchitis virus.";
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Brooks J.E., Rainer A.C., Parr R.L., Collisson E.W.;
RT   "Comparisons of the membrane protein genes of various strains of avian
RT   infectious bronchitis virus.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the viral envelope that plays a central role in
CC       virus morphogenesis and assembly via its interactions with other viral
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_04203, ECO:0000255|PROSITE-
CC       ProRule:PRU01275}.
CC   -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Forms a complex with HE and S
CC       proteins. Interacts with nucleocapsid N protein. This interaction
CC       probably participates in RNA packaging into the virus.
CC       {ECO:0000255|HAMAP-Rule:MF_04203, ECO:0000255|PROSITE-
CC       ProRule:PRU01275}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04203}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04203}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04203}. Note=Largely embedded in the lipid bilayer.
CC       {ECO:0000255|HAMAP-Rule:MF_04203}.
CC   -!- SIMILARITY: Belongs to the gammacoronaviruses M protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04203}.
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DR   EMBL; AY044184; AAK91808.1; -; mRNA.
DR   EMBL; AF286185; AAK83031.1; -; mRNA.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule.
DR   CDD; cd21566; gammaCoV_M; 1.
DR   HAMAP; MF_04203; GAMMA_CORONA_M; 1.
DR   InterPro; IPR042550; GAMMA_CORONA_M.
DR   InterPro; IPR002574; M_CoV.
DR   Pfam; PF01635; CoV_M; 1.
DR   PROSITE; PS51927; COV_M; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Viral matrix protein; Virion.
FT   CHAIN           1..225
FT                   /note="Membrane protein"
FT                   /id="PRO_0000106058"
FT   TOPO_DOM        1..20
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TOPO_DOM        42..51
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TRANSMEM        52..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TOPO_DOM        73..77
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   TOPO_DOM        99..225
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04203"
FT   CONFLICT        204
FT                   /note="A -> S (in Ref. 2; AAK91808)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   225 AA;  25539 MW;  FEAB5E27E962664F CRC64;
     MSNETNCTLD FEQSVELFKE YNLFITAFLL FLTIILQYGY ATRSKFIYIL KMIVLWCFWP
     LNIAVGVISC IYPPNTGGLV AAIILTVFAC LSFVGYWIQS IRLFKRCRSW WSFNPESNAV
     GSILLTNGQQ CNFAIESVPM VLSPIIKNGV LYCEGQWLAK CEPDHLPKDI FVCTPDRRNI
     YRMVQKYTGD QSGNKKRFAT FVYAKQSVDT GELESVATGG SSLYT