VME1_PEDVB
ID VME1_PEDVB Reviewed; 226 AA.
AC P59770; Q07504;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2003, sequence version 1.
DT 23-FEB-2022, entry version 75.
DE RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04201};
DE Short=M protein {ECO:0000255|HAMAP-Rule:MF_04201};
DE AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
DE AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
DE AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
GN Name=M {ECO:0000255|HAMAP-Rule:MF_04201}; ORFNames=5;
OS Porcine epidemic diarrhea virus (strain Br1/87) (PEDV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC Alphacoronavirus; Pedacovirus.
OX NCBI_TaxID=229033;
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=8291230; DOI=10.1006/viro.1994.1058;
RA Duarte M., Tobler K., Bridgen A., Rasschaert D., Ackermann M., Laude H.;
RT "Sequence analysis of the porcine epidemic diarrhea virus genome between
RT the nucleocapsid and spike protein genes reveals a polymorphic ORF.";
RL Virology 198:466-476(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 220-226.
RX PubMed=8397280; DOI=10.1099/0022-1317-74-9-1795;
RA Bridgen A., Duarte M., Tobler K., Laude H., Ackermann M.;
RT "Sequence determination of the nucleocapsid protein gene of the porcine
RT epidemic diarrhea virus confirms that this virus is a coronavirus related
RT to human coronavirus 229E and porcine transmissible gastroenteritis
RT virus.";
RL J. Gen. Virol. 74:1795-1804(1993).
CC -!- FUNCTION: Component of the viral envelope that plays a central role in
CC virus morphogenesis and assembly via its interactions with other viral
CC proteins. {ECO:0000255|HAMAP-Rule:MF_04201, ECO:0000255|PROSITE-
CC ProRule:PRU01275}.
CC -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Forms a complex with HE and S
CC proteins. Interacts with nucleocapsid N protein. This interaction
CC probably participates in RNA packaging into the virus.
CC {ECO:0000255|HAMAP-Rule:MF_04201, ECO:0000255|PROSITE-
CC ProRule:PRU01275}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC Rule:MF_04201}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04201}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC Rule:MF_04201}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_04201}. Note=Largely embedded in the lipid bilayer.
CC {ECO:0000255|HAMAP-Rule:MF_04201}.
CC -!- SIMILARITY: Belongs to the alphacoronaviruses M protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04201}.
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DR EMBL; Z24733; CAA80857.1; -; Genomic_RNA.
DR EMBL; Z14976; CAA78699.1; -; Genomic_RNA.
DR PIR; S37434; S37434.
DR SMR; P59770; -.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule.
DR CDD; cd21564; alphaCoV_M; 1.
DR HAMAP; MF_04201; ALPHA_CORONA_M; 1.
DR InterPro; IPR042551; ALPHA_CORONA_M.
DR InterPro; IPR002574; M_CoV.
DR Pfam; PF01635; CoV_M; 1.
DR PROSITE; PS51927; COV_M; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW Transmembrane helix; Viral envelope protein; Viral matrix protein; Virion.
FT CHAIN 1..226
FT /note="Membrane protein"
FT /id="PRO_0000106039"
FT TOPO_DOM 1..11
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TOPO_DOM 33..41
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TOPO_DOM 63..75
FT /note="Virion surface"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT TOPO_DOM 97..226
FT /note="Intravirion"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT REGION 200..216
FT /note="Interaction with N protein"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
SQ SEQUENCE 226 AA; 25360 MW; A6BAF44396E85473 CRC64;
MSNGSIPVDE VIEHLRNWNF TWNIILTILL VVLQYGHYKY SVFLYGVKMA ILWILWPLVL
ALSLFDAWAS FQVNWVFFAF SILMACITLM LWIMYFVNSI RLWRRTHSWW SFNPETDALL
TTSVMGRQVC IPVLGAPTGV TLTLLSGTLL VEGYKVATGV QVSQLPNFVT VAKATTTIVY
GRVGRSVNAS SGTGWAFYVR SKHGDYSAVS NPSAVLTDSE KVPHLV
