VMO1_CHICK
ID VMO1_CHICK Reviewed; 183 AA.
AC P41366;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Vitelline membrane outer layer protein 1;
DE Short=VMO-1;
DE Short=VMO-I;
DE Short=VMOI;
DE Flags: Precursor;
GN Name=VMO1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Oviduct;
RX PubMed=8039720; DOI=10.1016/0378-1119(94)90397-2;
RA Uyeda A., Inuzuka C., Doi Y., Kido S., Kikuchi M.;
RT "Cloning and sequencing of hen magnum cDNAs encoding vitelline membrane
RT outer layer protein I (VMO-I).";
RL Gene 144:311-312(1994).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
RX PubMed=8131734; DOI=10.1002/j.1460-2075.1994.tb06348.x;
RA Shimizu T., Vassylyev D.G., Kido S., Doi Y., Morikawa K.;
RT "Crystal structure of vitelline membrane outer layer protein I (VMO-I): a
RT folding motif with homologous Greek key structures related by an internal
RT three-fold symmetry.";
RL EMBO J. 13:1003-1010(1994).
RN [3]
RP REVIEW.
RX PubMed=8848836; DOI=10.1016/s0968-0004(06)80018-6;
RA Shimizu T., Morikawa K.;
RT "The beta-prism: a new folding motif.";
RL Trends Biochem. Sci. 21:3-6(1996).
CC -!- FUNCTION: Exact function not known, component of the outer membrane of
CC the vitelline layer of the egg. Seems to be able to synthesize N-
CC acetylchito-oligosaccharides (n=14-15) from hexasaccharides of N-
CC acetylglucosamine in a manner similar to the transferase activity of
CC lysozyme.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the VMO1 family. {ECO:0000305}.
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DR EMBL; D26093; BAA05086.1; -; mRNA.
DR PIR; I50442; I50442.
DR RefSeq; NP_001161233.1; NM_001167761.1.
DR PDB; 1VMO; X-ray; 2.20 A; A/B=21-183.
DR PDBsum; 1VMO; -.
DR AlphaFoldDB; P41366; -.
DR SMR; P41366; -.
DR STRING; 9031.ENSGALP00000029440; -.
DR PaxDb; P41366; -.
DR Ensembl; ENSGALT00000030078; ENSGALP00000029440; ENSGALG00000017172.
DR GeneID; 418974; -.
DR KEGG; gga:418974; -.
DR CTD; 284013; -.
DR VEuPathDB; HostDB:geneid_418974; -.
DR eggNOG; ENOG502S24T; Eukaryota.
DR GeneTree; ENSGT00390000009313; -.
DR HOGENOM; CLU_111176_1_0_1; -.
DR InParanoid; P41366; -.
DR OMA; CQDDSIT; -.
DR OrthoDB; 1368895at2759; -.
DR PhylomeDB; P41366; -.
DR TreeFam; TF315374; -.
DR EvolutionaryTrace; P41366; -.
DR PRO; PR:P41366; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000017172; Expressed in ovary.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR CDD; cd00220; VMO-I; 1.
DR Gene3D; 2.100.10.20; -; 1.
DR InterPro; IPR005515; VOMI.
DR InterPro; IPR036706; VOMI_sf.
DR PANTHER; PTHR18841; PTHR18841; 1.
DR Pfam; PF03762; VOMI; 1.
DR SUPFAM; SSF51092; SSF51092; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT CHAIN 21..183
FT /note="Vitelline membrane outer layer protein 1"
FT /id="PRO_0000036406"
FT DISULFID 46..77
FT DISULFID 99..130
FT DISULFID 153..181
FT DISULFID 156..182
FT STRAND 26..29
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 32..34
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 38..40
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 47..49
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 51..58
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 63..65
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 72..77
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 89..93
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 100..102
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 104..111
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 125..130
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 135..137
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 144..146
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 155..164
FT /evidence="ECO:0007829|PDB:1VMO"
FT TURN 169..171
FT /evidence="ECO:0007829|PDB:1VMO"
FT STRAND 173..181
FT /evidence="ECO:0007829|PDB:1VMO"
SQ SEQUENCE 183 AA; 20234 MW; 34713F305DF80413 CRC64;
MKVLTPAALI LLFFFYTVDA RTREYTSVIT VPNGGHWGKW GIRQFCHSGY ANGFALKVEP
SQFGRDDTAL NGIRLRCLDG SVIESLVGKW GTWTSFLVCP TGYLVSFSLR SEKSQGGGDD
TAANNIQFRC SDEAVLVGDG LSWGRFGPWS KRCKICGLQT KVESPQGLRD DTALNNVRFF
CCK
