VMO1_HUMAN
ID VMO1_HUMAN Reviewed; 202 AA.
AC Q7Z5L0; C9JQ15; E9PAU9; E9PGP4; Q3SXP1; Q8IUY1;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Vitelline membrane outer layer protein 1 homolog;
DE Flags: Precursor;
GN Name=VMO1; ORFNames=UNQ6350/PRO21055;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Ding P., Han W., Ying W., Liu Y., Wang L., Qiu X., Ma D.;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT ALA-26.
RG The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute;
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Alveolar macrophage;
RG The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ALA-26.
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 25-39.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q7Z5L0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z5L0-2; Sequence=VSP_045706, VSP_045707;
CC Name=3;
CC IsoId=Q7Z5L0-3; Sequence=VSP_045708;
CC Name=4;
CC IsoId=Q7Z5L0-4; Sequence=VSP_047219;
CC -!- SIMILARITY: Belongs to the VMO1 family. {ECO:0000305}.
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DR EMBL; AF521892; AAP80865.1; -; mRNA.
DR EMBL; BE669879; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY359099; AAQ89457.1; -; mRNA.
DR EMBL; CD367473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC233723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC038467; AAH38467.1; -; mRNA.
DR EMBL; BC104195; AAI04196.1; -; mRNA.
DR CCDS; CCDS11055.1; -. [Q7Z5L0-1]
DR CCDS; CCDS45585.1; -. [Q7Z5L0-2]
DR CCDS; CCDS45586.1; -. [Q7Z5L0-3]
DR CCDS; CCDS45587.1; -. [Q7Z5L0-4]
DR RefSeq; NP_001138411.1; NM_001144939.1. [Q7Z5L0-4]
DR RefSeq; NP_001138412.1; NM_001144940.1. [Q7Z5L0-3]
DR RefSeq; NP_001138413.1; NM_001144941.1. [Q7Z5L0-2]
DR RefSeq; NP_872372.1; NM_182566.2. [Q7Z5L0-1]
DR AlphaFoldDB; Q7Z5L0; -.
DR SMR; Q7Z5L0; -.
DR STRING; 9606.ENSP00000328397; -.
DR iPTMnet; Q7Z5L0; -.
DR PhosphoSitePlus; Q7Z5L0; -.
DR BioMuta; VMO1; -.
DR DMDM; 60390935; -.
DR jPOST; Q7Z5L0; -.
DR MassIVE; Q7Z5L0; -.
DR PaxDb; Q7Z5L0; -.
DR PeptideAtlas; Q7Z5L0; -.
DR PRIDE; Q7Z5L0; -.
DR ProteomicsDB; 11185; -.
DR ProteomicsDB; 19084; -.
DR ProteomicsDB; 20361; -.
DR ProteomicsDB; 69315; -. [Q7Z5L0-1]
DR Antibodypedia; 51551; 70 antibodies from 17 providers.
DR DNASU; 284013; -.
DR Ensembl; ENST00000328739.6; ENSP00000328397.5; ENSG00000182853.12. [Q7Z5L0-1]
DR Ensembl; ENST00000354194.4; ENSP00000346133.4; ENSG00000182853.12. [Q7Z5L0-2]
DR Ensembl; ENST00000416307.6; ENSP00000390450.2; ENSG00000182853.12. [Q7Z5L0-3]
DR Ensembl; ENST00000441199.2; ENSP00000408166.2; ENSG00000182853.12. [Q7Z5L0-4]
DR GeneID; 284013; -.
DR KEGG; hsa:284013; -.
DR MANE-Select; ENST00000328739.6; ENSP00000328397.5; NM_182566.3; NP_872372.1.
DR UCSC; uc002fyx.4; human. [Q7Z5L0-1]
DR CTD; 284013; -.
DR DisGeNET; 284013; -.
DR GeneCards; VMO1; -.
DR HGNC; HGNC:30387; VMO1.
DR HPA; ENSG00000182853; Tissue enhanced (lymphoid tissue, pituitary gland).
DR neXtProt; NX_Q7Z5L0; -.
DR OpenTargets; ENSG00000182853; -.
DR PharmGKB; PA142670619; -.
DR VEuPathDB; HostDB:ENSG00000182853; -.
DR eggNOG; ENOG502S05N; Eukaryota.
DR GeneTree; ENSGT00390000009313; -.
DR HOGENOM; CLU_2269772_0_0_1; -.
DR InParanoid; Q7Z5L0; -.
DR OMA; DWSDHCP; -.
DR OrthoDB; 1368895at2759; -.
DR PhylomeDB; Q7Z5L0; -.
DR TreeFam; TF315374; -.
DR PathwayCommons; Q7Z5L0; -.
DR BioGRID-ORCS; 284013; 11 hits in 1064 CRISPR screens.
DR GenomeRNAi; 284013; -.
DR Pharos; Q7Z5L0; Tbio.
DR PRO; PR:Q7Z5L0; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q7Z5L0; protein.
DR Bgee; ENSG00000182853; Expressed in nasal cavity epithelium and 103 other tissues.
DR Genevisible; Q7Z5L0; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR CDD; cd00220; VMO-I; 1.
DR Gene3D; 2.100.10.20; -; 1.
DR InterPro; IPR005515; VOMI.
DR InterPro; IPR036706; VOMI_sf.
DR PANTHER; PTHR18841; PTHR18841; 1.
DR Pfam; PF03762; VOMI; 1.
DR SUPFAM; SSF51092; SSF51092; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 25..202
FT /note="Vitelline membrane outer layer protein 1 homolog"
FT /id="PRO_0000036407"
FT DISULFID 53..86
FT /evidence="ECO:0000250"
FT DISULFID 114..146
FT /evidence="ECO:0000250"
FT DISULFID 169..199
FT /evidence="ECO:0000250"
FT DISULFID 174..200
FT /evidence="ECO:0000250"
FT VAR_SEQ 66..70
FT /note="VEPPQ -> LGRME (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045706"
FT VAR_SEQ 71..202
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045707"
FT VAR_SEQ 98..202
FT /note="VESQSGSWGEWSEPLWCRGGAYLVAFSLRVEAPTTLGDNTAANNVRFRCSDG
FT EELQGPGLSWGDFGDWSDHCPKGACGLQTKIQGPRGLGDDTALNDARLFCCRS -> LG
FT RME (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_045708"
FT VAR_SEQ 104..202
FT /note="SWGEWSEPLWCRGGAYLVAFSLRVEAPTTLGDNTAANNVRFRCSDGEELQGP
FT GLSWGDFGDWSDHCPKGACGLQTKIQGPRGLGDDTALNDARLFCCRS -> RWGAGVED
FT PLG (in isoform 4)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_047219"
FT VARIANT 26
FT /note="T -> A (in dbSNP:rs4790706)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_053736"
FT VARIANT 77
FT /note="T -> S (in dbSNP:rs2279961)"
FT /id="VAR_034584"
SQ SEQUENCE 202 AA; 21534 MW; 5C62A561693EE086 CRC64;
MERGAGAKLL PLLLLLRATG FTCAQTDGRN GYTAVIEVTS GGPWGDWAWP EMCPDGFFAS
GFSLKVEPPQ GIPGDDTALN GIRLHCARGN VLGNTHVVES QSGSWGEWSE PLWCRGGAYL
VAFSLRVEAP TTLGDNTAAN NVRFRCSDGE ELQGPGLSWG DFGDWSDHCP KGACGLQTKI
QGPRGLGDDT ALNDARLFCC RS
