VMS1_SCHPO
ID VMS1_SCHPO Reviewed; 600 AA.
AC O74977;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=VMS1 homolog C1827.04;
GN ORFNames=SPCC1827.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Involved in the endoplasmic reticulum (ER)-associated
CC degradation (ERAD) pathway. Component of an evolutionarily conserved
CC system for ubiquitin-mediated mitochondria-associated protein
CC degradation (MAD), which is necessary to maintain mitochondrial,
CC cellular, and organismal viability (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC Mitochondrion {ECO:0000250}. Endoplasmic reticulum membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ANKZF1/VMS1 family. {ECO:0000305}.
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DR EMBL; CU329672; CAA19312.1; -; Genomic_DNA.
DR PIR; T41165; T41165.
DR RefSeq; NP_588550.1; NM_001023537.2.
DR AlphaFoldDB; O74977; -.
DR SMR; O74977; -.
DR BioGRID; 275759; 27.
DR STRING; 4896.SPCC1827.04.1; -.
DR iPTMnet; O74977; -.
DR MaxQB; O74977; -.
DR PaxDb; O74977; -.
DR PRIDE; O74977; -.
DR EnsemblFungi; SPCC1827.04.1; SPCC1827.04.1:pep; SPCC1827.04.
DR PomBase; SPCC1827.04; -.
DR VEuPathDB; FungiDB:SPCC1827.04; -.
DR eggNOG; KOG2505; Eukaryota.
DR HOGENOM; CLU_014293_1_1_1; -.
DR InParanoid; O74977; -.
DR OMA; QKTIHRY; -.
DR PhylomeDB; O74977; -.
DR PRO; PR:O74977; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0036266; C:Cdc48p-Npl4p-Vms1p AAA ATPase complex; ISO:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:PomBase.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; ISO:PomBase.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR041175; VLRF1/Vms1.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF18826; bVLRF1; 1.
DR SMART; SM00248; ANK; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Coiled coil; Cytoplasm; Endoplasmic reticulum; Membrane;
KW Mitochondrion; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..600
FT /note="VMS1 homolog C1827.04"
FT /id="PRO_0000310323"
FT REPEAT 432..461
FT /note="ANK 1"
FT REPEAT 465..492
FT /note="ANK 2"
FT REGION 239..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 359..392
FT /evidence="ECO:0000255"
FT COILED 506..550
FT /evidence="ECO:0000255"
FT COMPBIAS 242..261
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 38
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 600 AA; 68793 MW; 5FA84FA561153037 CRC64;
MGDISKHNIF SLPEDILAKL ELREEYSVEE KTDSANLSNQ GDIVDSTQKN ISSCVNCQID
NLHTLDERKS HIKSDWHRFN TKRKITKLPP VSQDEFESII EDLPESLSGS ESETNSESEE
DNFQIEKAFK QSLNIGKVDS ADENNNQRTN SPLTWFQLSN ASAEVPTYIG VYKHMFSGNN
HITKDLLVQQ QNHNRQKPLQ LAMFMVGGGH FAAMIASNEF NPRDPHVPKV LAQKTIHRYT
TRRKQGGSQG AADNTKGNIH SAGSGLRRYN EQALIKDIQQ VFKDWGKLLE TCDLIFVRAI
GSSNRSIFFS QPGALISPKD PKLRVFPFTT KRATHSELLR CYKELVTPKI SHVDSISIKA
QEEERKRQAE IEKEIRQSRL QEEERKKKKL AKYTEVIISN LKASNIEAFL EYLRSNDLSI
NFQFYPKNVH LHTSTPLHYA VTQKNAKLVA KLLRNGADPA MLNGNGKTPF EISTGNKEVK
DEFLIARHEL GESFFDWEAA KVGAPQSREQ IQKQRQKAKT KLENQRRDKE RQEELRRKEA
MQKIEEQSKR DYDKLHGEGH SLGINNVRKV DELQSLSPEM RMRIEREKRA AAAMKRMQTK
