ID   VMT8_MYXVL              Reviewed;         515 AA.
AC   P22611; Q9PWV1;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2002, sequence version 2.
DT   23-FEB-2022, entry version 95.
DE   RecName: Full=Kelch repeat protein M-T8;
GN   OrderedLocusNames=m008L;
OS   Myxoma virus (strain Lausanne) (MYXV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=31530;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562494; DOI=10.1006/viro.1999.0001;
RA   Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X.,
RA   Macaulay C., Willer D.O., Evans D.H., McFadden G.;
RT   "The complete DNA sequence of myxoma virus.";
RL   Virology 264:298-318(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-251.
RX   PubMed=2173255; DOI=10.1016/0042-6822(90)90129-f;
RA   Upton C., Macen J.L., Wishart D.S., McFadden G.;
RT   "Myxoma virus and malignant rabbit fibroma virus encode a serpin-like
RT   protein important for virus virulence.";
RL   Virology 179:618-631(1990).
CC   -!- SIMILARITY: Belongs to the poxviruses Kelch family. {ECO:0000305}.
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DR   EMBL; AF170726; AAF14895.1; -; Genomic_DNA.
DR   EMBL; AF170726; AAF15054.1; -; Genomic_DNA.
DR   EMBL; M35233; AAA46630.1; -; Genomic_DNA.
DR   PIR; C36418; C36418.
DR   RefSeq; NP_051721.1; NC_001132.2.
DR   RefSeq; NP_051871.1; NC_001132.2.
DR   SMR; P22611; -.
DR   PRIDE; P22611; -.
DR   GeneID; 932082; -.
DR   GeneID; 932179; -.
DR   KEGG; vg:932082; -.
DR   KEGG; vg:932179; -.
DR   Proteomes; UP000000867; Genome.
DR   Gene3D; 2.120.10.80; -; 2.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR024182; Vaccinia_A55R.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   PIRSF; PIRSF003716; VAC_F3L; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 4.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..515
FT                   /note="Kelch repeat protein M-T8"
FT                   /id="PRO_0000119170"
FT   DOMAIN          16..82
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REPEAT          280..326
FT                   /note="Kelch 1"
FT   REPEAT          328..374
FT                   /note="Kelch 2"
FT   REPEAT          376..423
FT                   /note="Kelch 3"
FT   REPEAT          424..471
FT                   /note="Kelch 4"
FT   REPEAT          473..512
FT                   /note="Kelch 5"
SQ   SEQUENCE   515 AA;  59021 MW;  E1B3E3D2F0FB4385 CRC64;
     MMSYPLYKLF LKGKLCDVEI VAEGKSIRAH RLVLSAYSKY FYNLFNGNFL EKNVDVIDLE
     ADYKTVFDVI YYMYTESIEL HKGNTESIFS LVHYLQIKPL IKKCIYEFNS IVNEENCIRL
     FKFAELYDLS ELKRRARWLM PSLVMNEKDR LREMSLDDLS LMLVQIRNTV DRSIALSAIT
     EWIQTNVRER RRHAVHLATC LGDVPGTASS RAVYKHYMSE LRIRVTEFQP AYHNCVVYLG
     GSMKGRVTAL DPETGKSVVL STWWPEERWE CFTAVCMNDV LYFAGGKLDA VPTRQVLSYD
     VKANTWSRQP NLSEFRSDAA AYAIGGCIYI IGGYDANDRP TNTTLYWRPG YDRWYRGPTL
     VEAVAETSAV CYKNEIWVLG GRIHRDGVPD VTDVVQKLSG GTWTKVNELS VPKASVTAIV
     YKERLYCVGG LVDRYAPTNE VIRYRDDTNE WEYVGSTKIE RGGAVGCVYN DELYVFGGTD
     TFTSERYNGV IWKRANDVSC HFATMNAAYA TYLEL