ID   VMXP_TITSE              Reviewed;          86 AA.
AC   P85842;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=Venom metalloproteinase;
DE            Short=VMP;
DE            EC=3.4.24.-;
DE   Flags: Fragments;
OS   Tityus serrulatus (Brazilian scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=6887;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Venom {ECO:0000269|Ref.1};
RA   Richardson M., Borges M.H., Cordeiro M.N., Pimenta A.M.C., de Lima M.E.,
RA   Rates B.;
RT   "Metalloproteinase from venom of Brazilian scorpion Tityus serrulatus.";
RL   Submitted (MAY-2008) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
CC   -!- SIMILARITY: Belongs to the venom metalloproteinase (M12B) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P85842; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
PE   1: Evidence at protein level;
KW   Calcium; Direct protein sequencing; Hydrolase; Metal-binding;
KW   Metalloprotease; Protease; Secreted; Toxin; Zinc.
FT   CHAIN           1..>86
FT                   /note="Venom metalloproteinase"
FT                   /id="PRO_0000343514"
FT   ACT_SITE        68
FT                   /evidence="ECO:0000250|UniProtKB:Q9PW35"
FT   BINDING         7
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   BINDING         67
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         71
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   BINDING         77
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250"
FT   NON_CONS        48..49
FT                   /evidence="ECO:0000303|Ref.1"
FT   NON_TER         86
FT                   /evidence="ECO:0000303|Ref.1"
SQ   SEQUENCE   86 AA;  9642 MW;  F753669979BC2353 CRC64;
     SPCIIIDYLC VTETCFCERF KTNKELLEYI TVMFTGVQNL LDTLNLGIVG VAQDYSDYNE
     RVDTVAHETA HLIGAPHDEE GPCQDT