VN1A8_MOUSE
ID VN1A8_MOUSE Reviewed; 279 AA.
AC Q9EQ48; B9EHS8;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Vomeronasal type-1 receptor A8;
GN Name=V1ra8 {ECO:0000312|EMBL:AAG42081.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42081.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42081.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=11802169; DOI=10.1038/nn795;
RA Rodriguez I., Del Punta K., Rothman A., Ishii T., Mombaerts P.;
RT "Multiple new and isolated families within the mouse superfamily of V1r
RT vomeronasal receptors.";
RL Nat. Neurosci. 5:134-140(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in
CC the apical layer of the vomeronasal organ.
CC {ECO:0000269|PubMed:11802169}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291487; AAG42081.1; -; Genomic_DNA.
DR EMBL; BC138392; AAI38393.1; -; mRNA.
DR EMBL; BC138394; AAI38395.1; -; mRNA.
DR CCDS; CCDS20354.1; -.
DR RefSeq; NP_444453.1; NM_053223.1.
DR AlphaFoldDB; Q9EQ48; -.
DR SMR; Q9EQ48; -.
DR GlyGen; Q9EQ48; 1 site.
DR PaxDb; Q9EQ48; -.
DR PRIDE; Q9EQ48; -.
DR DNASU; 113850; -.
DR Ensembl; ENSMUST00000078371; ENSMUSP00000077479; ENSMUSG00000062546.
DR GeneID; 113850; -.
DR KEGG; mmu:113850; -.
DR UCSC; uc009cwx.1; mouse.
DR CTD; 113850; -.
DR MGI; MGI:2148513; V1ra8.
DR VEuPathDB; HostDB:ENSMUSG00000062546; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q9EQ48; -.
DR OMA; ISMYERI; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9EQ48; -.
DR BioGRID-ORCS; 113850; 3 hits in 36 CRISPR screens.
DR PRO; PR:Q9EQ48; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9EQ48; protein.
DR Bgee; ENSMUSG00000062546; Expressed in uterus.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..279
FT /note="Vomeronasal type-1 receptor A8"
FT /id="PRO_0000239964"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..159
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..187
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..279
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 279 AA; 31564 MW; 68C5CC1BAE50982D CRC64;
MNKDHTLYCS VYIRNAFFSE IGIGISANSC LLLFHTFMFI RGHRPRLTDL PIGFVALIHL
VMLLLAAYIT EDFFMSSGGW DDITCKLVIF LHRFFRSLSV CATCLLSVFQ AIILCPQSSH
LAKLKQNSPH QLSYFFIFLS IFYTSISSQI LIAAIPTQNI TFVNLIYITN SCSFLPLSSS
MQHTFSTLLT FRNVFVIGLM GLSTCYMATL LCRHKTRSQR LQNSKLSPKA TPEQRALRTI
LMLMSFFLLM STFDSIISYS RTIITGKSTA LLCPDSCRS
