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VN1R1_GORGO
ID   VN1R1_GORGO             Reviewed;         353 AA.
AC   Q8WN92; Q7YRP4;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Vomeronasal type-1 receptor 1;
DE   AltName: Full=V1r-like receptor 1;
GN   Name=VN1R1; Synonyms=V1RL1;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12142329; DOI=10.1093/chemse/27.6.529;
RA   Giorgi D., Rouquier S.;
RT   "Identification of V1R-like putative pheromone receptor sequences in non-
RT   human primates. Characterization of V1R pseudogenes in marmoset, a primate
RT   species that possesses an intact vomeronasal organ.";
RL   Chem. Senses 27:529-537(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12826614; DOI=10.1073/pnas.1331721100;
RA   Zhang J., Webb D.M.;
RT   "Evolutionary deterioration of the vomeronasal pheromone transduction
RT   pathway in catarrhine primates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
CC   -!- FUNCTION: Putative pheromone receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF426107; AAL60180.1; -; Genomic_DNA.
DR   EMBL; AY312464; AAP85608.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8WN92; -.
DR   SMR; Q8WN92; -.
DR   STRING; 9593.ENSGGOP00000022152; -.
DR   eggNOG; ENOG502RD1P; Eukaryota.
DR   InParanoid; Q8WN92; -.
DR   Proteomes; UP000001519; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR   GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR004072; Vmron_rcpt_1.
DR   PANTHER; PTHR24062; PTHR24062; 1.
DR   Pfam; PF03402; V1R; 1.
DR   PRINTS; PR01534; VOMERONASL1R.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Pheromone response; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..353
FT                   /note="Vomeronasal type-1 receptor 1"
FT                   /id="PRO_0000070212"
FT   TOPO_DOM        1..56
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..84
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..132
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        154..169
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..226
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        248..274
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..303
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        304..324
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        325..353
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        117
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        198
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        216
FT                   /note="F -> L (in Ref. 2; AAP85608)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   353 AA;  40215 MW;  449F3EC549DF3BD5 CRC64;
     MVGDTLKLLS PLMTRYFFLL FYSTDSSDLN ENQHPLDFDE MAFGKVKSGI SFLIQTGVGI
     LGNSFLLCFY NLILFTGHKL RPTDLILSHL ALANSMVLFF KGIPQTMAAF GLKYLLNDTG
     CKFVFYYHRV GTRVSLSTIC LLNGFQAIKL NPSICRWMEI KIRSPRFIDF CCLLCWVPHV
     LMNASVLLLV NGPLNSKNSS AKNNYGYCSY KASKRFSSLH AVLYFSPDFM SLGFMVWASG
     SMVFFLYRHK QQVQHNHSNR LSCRPSQETR ATRTIMVLVS SFFVFYSVHS FLTIWTTVVA
     NPGQWIVNNS VLVASYFPSR SPFVLIMSDT RISQFCFACR TRKTLFPNLV VMP
 
 
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