VN1R1_GORGO
ID VN1R1_GORGO Reviewed; 353 AA.
AC Q8WN92; Q7YRP4;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Vomeronasal type-1 receptor 1;
DE AltName: Full=V1r-like receptor 1;
GN Name=VN1R1; Synonyms=V1RL1;
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12142329; DOI=10.1093/chemse/27.6.529;
RA Giorgi D., Rouquier S.;
RT "Identification of V1R-like putative pheromone receptor sequences in non-
RT human primates. Characterization of V1R pseudogenes in marmoset, a primate
RT species that possesses an intact vomeronasal organ.";
RL Chem. Senses 27:529-537(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12826614; DOI=10.1073/pnas.1331721100;
RA Zhang J., Webb D.M.;
RT "Evolutionary deterioration of the vomeronasal pheromone transduction
RT pathway in catarrhine primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
CC -!- FUNCTION: Putative pheromone receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF426107; AAL60180.1; -; Genomic_DNA.
DR EMBL; AY312464; AAP85608.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8WN92; -.
DR SMR; Q8WN92; -.
DR STRING; 9593.ENSGGOP00000022152; -.
DR eggNOG; ENOG502RD1P; Eukaryota.
DR InParanoid; Q8WN92; -.
DR Proteomes; UP000001519; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..353
FT /note="Vomeronasal type-1 receptor 1"
FT /id="PRO_0000070212"
FT TOPO_DOM 1..56
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..132
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..226
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..303
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 216
FT /note="F -> L (in Ref. 2; AAP85608)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 353 AA; 40215 MW; 449F3EC549DF3BD5 CRC64;
MVGDTLKLLS PLMTRYFFLL FYSTDSSDLN ENQHPLDFDE MAFGKVKSGI SFLIQTGVGI
LGNSFLLCFY NLILFTGHKL RPTDLILSHL ALANSMVLFF KGIPQTMAAF GLKYLLNDTG
CKFVFYYHRV GTRVSLSTIC LLNGFQAIKL NPSICRWMEI KIRSPRFIDF CCLLCWVPHV
LMNASVLLLV NGPLNSKNSS AKNNYGYCSY KASKRFSSLH AVLYFSPDFM SLGFMVWASG
SMVFFLYRHK QQVQHNHSNR LSCRPSQETR ATRTIMVLVS SFFVFYSVHS FLTIWTTVVA
NPGQWIVNNS VLVASYFPSR SPFVLIMSDT RISQFCFACR TRKTLFPNLV VMP