VN1R1_HUMAN
ID VN1R1_HUMAN Reviewed; 353 AA.
AC Q9GZP7; B3KSV5; Q7Z5H8; Q7Z5H9;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Vomeronasal type-1 receptor 1;
DE AltName: Full=G-protein coupled receptor GPCR24;
DE Short=hGPCR24;
DE AltName: Full=V1r-like receptor 1;
DE AltName: Full=V3r-related gene protein;
DE AltName: Full=Vomeronasal olfactory receptor chromosome 19 subtype I member 1;
GN Name=VN1R1; Synonyms=V1RL1, VNR19I1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANTS PHE-241 AND
RP ASP-269.
RX PubMed=10973240; DOI=10.1038/79124;
RA Rodriguez I., Greer C.A., Mok M.Y., Mombaerts P.;
RT "A putative pheromone receptor gene expressed in human olfactory mucosa.";
RL Nat. Genet. 26:18-19(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Holloway J., Lofton-Day C., Lok S.;
RT "Human pheromone receptor ortholog subtype I member 1.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS THR-139; PHE-241 AND
RP ASP-269.
RX PubMed=12826614; DOI=10.1073/pnas.1331721100;
RA Zhang J., Webb D.M.;
RT "Evolutionary deterioration of the vomeronasal pheromone transduction
RT pathway in catarrhine primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative pheromone receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in the olfactory mucosa, very low
CC expression in brain, lung and kidney. {ECO:0000269|PubMed:10973240}.
CC -!- MISCELLANEOUS: The chimpanzee and orangutan orthologous proteins do not
CC exist, their genes are pseudogenes.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of
CC August 2005;
CC URL="https://web.expasy.org/spotlight/back_issues/061";
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DR EMBL; AF255342; AAG10698.1; -; mRNA.
DR EMBL; AF302903; AAG22545.1; -; mRNA.
DR EMBL; AY312477; AAP85612.1; -; Genomic_DNA.
DR EMBL; AY312478; AAP85613.1; -; Genomic_DNA.
DR EMBL; AY312479; AAP85614.1; -; Genomic_DNA.
DR EMBL; AK094452; BAG52867.1; -; mRNA.
DR EMBL; AB083606; BAB89319.1; -; Genomic_DNA.
DR EMBL; CH471135; EAW72503.1; -; Genomic_DNA.
DR EMBL; BC095508; AAH95508.1; -; mRNA.
DR CCDS; CCDS12951.1; -.
DR RefSeq; NP_065684.1; NM_020633.3.
DR AlphaFoldDB; Q9GZP7; -.
DR SMR; Q9GZP7; -.
DR BioGRID; 121440; 3.
DR IntAct; Q9GZP7; 3.
DR STRING; 9606.ENSP00000322339; -.
DR TCDB; 9.A.14.12.1; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; Q9GZP7; 2 sites.
DR iPTMnet; Q9GZP7; -.
DR PhosphoSitePlus; Q9GZP7; -.
DR BioMuta; VN1R1; -.
DR DMDM; 71153399; -.
DR PaxDb; Q9GZP7; -.
DR PRIDE; Q9GZP7; -.
DR Antibodypedia; 19649; 183 antibodies from 26 providers.
DR DNASU; 57191; -.
DR Ensembl; ENST00000321039.5; ENSP00000322339.3; ENSG00000178201.5.
DR GeneID; 57191; -.
DR KEGG; hsa:57191; -.
DR MANE-Select; ENST00000321039.5; ENSP00000322339.3; NM_020633.4; NP_065684.1.
DR UCSC; uc002qos.3; human.
DR CTD; 57191; -.
DR DisGeNET; 57191; -.
DR GeneCards; VN1R1; -.
DR HGNC; HGNC:13548; VN1R1.
DR HPA; ENSG00000178201; Tissue enhanced (retina).
DR MIM; 605234; gene.
DR neXtProt; NX_Q9GZP7; -.
DR OpenTargets; ENSG00000178201; -.
DR PharmGKB; PA134957891; -.
DR VEuPathDB; HostDB:ENSG00000178201; -.
DR eggNOG; ENOG502RD1P; Eukaryota.
DR GeneTree; ENSGT00960000186612; -.
DR HOGENOM; CLU_058641_1_0_1; -.
DR InParanoid; Q9GZP7; -.
DR OMA; ISQFCFA; -.
DR OrthoDB; 1219728at2759; -.
DR PhylomeDB; Q9GZP7; -.
DR PathwayCommons; Q9GZP7; -.
DR SignaLink; Q9GZP7; -.
DR BioGRID-ORCS; 57191; 30 hits in 1072 CRISPR screens.
DR GeneWiki; VN1R1; -.
DR GenomeRNAi; 57191; -.
DR Pharos; Q9GZP7; Tbio.
DR PRO; PR:Q9GZP7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9GZP7; protein.
DR Bgee; ENSG00000178201; Expressed in cerebellar cortex and 101 other tissues.
DR Genevisible; Q9GZP7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..353
FT /note="Vomeronasal type-1 receptor 1"
FT /id="PRO_0000070213"
FT TOPO_DOM 1..56
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..132
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..226
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..303
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..353
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 103
FT /note="I -> M (in dbSNP:rs3746223)"
FT /id="VAR_049452"
FT VARIANT 139
FT /note="I -> T (in allele VN1R1*2; dbSNP:rs374900565)"
FT /evidence="ECO:0000269|PubMed:12826614"
FT /id="VAR_022795"
FT VARIANT 241
FT /note="S -> F (in allele VN1R1*3; dbSNP:rs28649880)"
FT /evidence="ECO:0000269|PubMed:10973240,
FT ECO:0000269|PubMed:12826614"
FT /id="VAR_022796"
FT VARIANT 269
FT /note="A -> D (in allele VN1R1*3; dbSNP:rs61744949)"
FT /evidence="ECO:0000269|PubMed:10973240,
FT ECO:0000269|PubMed:12826614"
FT /id="VAR_022797"
SQ SEQUENCE 353 AA; 40021 MW; CCB0E9BAFA5EC021 CRC64;
MVGDTLKLLS PLMTRYFFLL FYSTDSSDLN ENQHPLDFDE MAFGKVKSGI SFLIQTGVGI
LGNSFLLCFY NLILFTGHKL RPTDLILSQL ALANSMVLFF KGIPQTMAAF GLKYLLNDTG
CKFVFYYHRV GTRVSLSTIC LLNGFQAIKL NPSICRWMEI KIRSPRFIDF CCLLCWAPHV
LMNASVLLLV NGPLNSKNSS AKNNYGYCSY KASKRFSSLH AVLYFSPDFM SLGFMVWASG
SMVFFLYRHK QQVQHNHSNR LSCRPSQEAR ATHTIMVLVS SFFVFYSVHS FLTIWTTVVA
NPGQWIVTNS VLVASCFPAR SPFVLIMSDT HISQFCFACR TRKTLFPNLV VMP
