VN1R2_HUMAN
ID VN1R2_HUMAN Reviewed; 395 AA.
AC Q8NFZ6; A1L411; Q8TDU4;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Vomeronasal type-1 receptor 2;
DE AltName: Full=G-protein coupled receptor GPCR25;
DE Short=hGPCR25;
DE AltName: Full=V1r-like receptor 2;
GN Name=VN1R2; Synonyms=V1RL2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ARG-38.
RX PubMed=12123587; DOI=10.1016/s0960-9822(02)00909-0;
RA Rodriguez I., Mombaerts P.;
RT "Novel human vomeronasal receptor-like genes reveal species-specific
RT families.";
RL Curr. Biol. 12:R409-R411(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12826614; DOI=10.1073/pnas.1331721100;
RA Zhang J., Webb D.M.;
RT "Evolutionary deterioration of the vomeronasal pheromone transduction
RT pathway in catarrhine primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ARG-38.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-38.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative pheromone receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: The chimpanzee, gorilla and orangutan orthologous
CC proteins do not exist, their genes are pseudogenes.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of
CC August 2005;
CC URL="https://web.expasy.org/spotlight/back_issues/061";
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DR EMBL; AF370359; AAM83034.1; -; Genomic_DNA.
DR EMBL; AY312480; AAP85615.1; -; Genomic_DNA.
DR EMBL; AY312481; AAP85616.1; -; Genomic_DNA.
DR EMBL; AY312482; AAP85617.1; -; Genomic_DNA.
DR EMBL; AB083607; BAB89320.1; -; Genomic_DNA.
DR EMBL; CH471135; EAW72126.1; -; Genomic_DNA.
DR EMBL; BC130356; AAI30357.1; -; mRNA.
DR EMBL; BC130358; AAI30359.1; -; mRNA.
DR CCDS; CCDS12862.1; -.
DR RefSeq; NP_776255.2; NM_173856.2.
DR AlphaFoldDB; Q8NFZ6; -.
DR SMR; Q8NFZ6; -.
DR BioGRID; 130443; 1.
DR IntAct; Q8NFZ6; 1.
DR STRING; 9606.ENSP00000351244; -.
DR GlyGen; Q8NFZ6; 2 sites.
DR BioMuta; VN1R2; -.
DR DMDM; 146337173; -.
DR MassIVE; Q8NFZ6; -.
DR PaxDb; Q8NFZ6; -.
DR PeptideAtlas; Q8NFZ6; -.
DR PRIDE; Q8NFZ6; -.
DR Antibodypedia; 32680; 129 antibodies from 20 providers.
DR DNASU; 317701; -.
DR Ensembl; ENST00000341702.3; ENSP00000351244.2; ENSG00000196131.6.
DR GeneID; 317701; -.
DR KEGG; hsa:317701; -.
DR MANE-Select; ENST00000341702.3; ENSP00000351244.2; NM_173856.2; NP_776255.2.
DR UCSC; uc002qbi.2; human.
DR CTD; 317701; -.
DR DisGeNET; 317701; -.
DR GeneCards; VN1R2; -.
DR HGNC; HGNC:19872; VN1R2.
DR HPA; ENSG00000196131; Not detected.
DR neXtProt; NX_Q8NFZ6; -.
DR PharmGKB; PA134969616; -.
DR VEuPathDB; HostDB:ENSG00000196131; -.
DR eggNOG; ENOG502RD1P; Eukaryota.
DR GeneTree; ENSGT00960000186612; -.
DR HOGENOM; CLU_058641_1_0_1; -.
DR InParanoid; Q8NFZ6; -.
DR OMA; WSNNNIT; -.
DR OrthoDB; 1155990at2759; -.
DR PhylomeDB; Q8NFZ6; -.
DR PathwayCommons; Q8NFZ6; -.
DR SignaLink; Q8NFZ6; -.
DR BioGRID-ORCS; 317701; 23 hits in 1067 CRISPR screens.
DR GeneWiki; VN1R2; -.
DR GenomeRNAi; 317701; -.
DR Pharos; Q8NFZ6; Tdark.
DR PRO; PR:Q8NFZ6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NFZ6; protein.
DR Bgee; ENSG00000196131; Expressed in right testis and 85 other tissues.
DR Genevisible; Q8NFZ6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..395
FT /note="Vomeronasal type-1 receptor 2"
FT /id="PRO_0000070214"
FT TRANSMEM 12..32
FT /note="Helical; Name=0"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..51
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..93
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..170
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 338..346
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 368..395
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 239
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 38
FT /note="C -> R (in dbSNP:rs2965249)"
FT /evidence="ECO:0000269|PubMed:12123587,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_022798"
SQ SEQUENCE 395 AA; 44476 MW; 0C32D3A611B2C4BD CRC64;
MTHTLYPTPF ALYPINISAA WHLGPLPVSC FVSNKYQCSL AFGATTGLRV LVVVVPQTQL
SFLSSLCLVS LFLHSLVSAH GEKPTKPVGL DPTLFQVVVG ILGNFSLLYY YMFLYFRGYK
PRSTDLILRH LTVADSLVIL SKRIPETMAT FGLKHFDNYF GCKFLLYAHR VGRGVSIGST
CLLSVFQVIT INPRNSRWAE MKVKAPTYIG LSNILCWAFH MLVNAIFPIY TTGKWSNNNI
TKKGDLGYCS APLSDEVTKS VYAALTSFHD VLCLGLMLWA SSSIVLVLYR HKQQVQHICR
NNLYPNSSPG NRAIQSILAL VSTFALCYAL SFITYVYLAL FDNSSWWLVN TAALIIACFP
TISPFVLMCR DPSRSRLCSI CCRRNRRFFH DFRKM
