VN1R3_HUMAN
ID VN1R3_HUMAN Reviewed; 311 AA.
AC Q9BXE9;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Vomeronasal type-1 receptor 3;
DE AltName: Full=V1r-like receptor 3;
GN Name=VN1R3; Synonyms=V1RL3; ORFNames=FKSG46;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wang Y.-G., Gong L.;
RT "Cloning and characterization of FKSG46, a novel gene located on human
RT chromosome 16.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12123587; DOI=10.1016/s0960-9822(02)00909-0;
RA Rodriguez I., Mombaerts P.;
RT "Novel human vomeronasal receptor-like genes reveal species-specific
RT families.";
RL Curr. Biol. 12:R409-R411(2002).
RN [3]
RP DISCUSSION OF POLYMORPHISM.
RX PubMed=12826614; DOI=10.1073/pnas.1331721100;
RA Zhang J., Webb D.M.;
RT "Evolutionary deterioration of the vomeronasal pheromone transduction
RT pathway in catarrhine primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
CC -!- FUNCTION: Putative pheromone receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: There seems to be a deletion in the gene coding for this
CC protein in about 98% of the population. {ECO:0000305|PubMed:12826614}.
CC -!- MISCELLANEOUS: The gorilla and orangutan orthologous proteins do not
CC exist, their genes are pseudogenes.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of
CC August 2005;
CC URL="https://web.expasy.org/spotlight/back_issues/061";
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DR EMBL; AF336873; AAK21299.1; -; mRNA.
DR RefSeq; NP_778145.2; NM_174980.2.
DR AlphaFoldDB; Q9BXE9; -.
DR SMR; Q9BXE9; -.
DR GlyGen; Q9BXE9; 1 site.
DR BioMuta; HGNC:19867; -.
DR DMDM; 68566227; -.
DR jPOST; Q9BXE9; -.
DR PeptideAtlas; Q9BXE9; -.
DR PRIDE; Q9BXE9; -.
DR DNASU; 317702; -.
DR GeneID; 317702; -.
DR KEGG; hsa:317702; -.
DR CTD; 317702; -.
DR GeneCards; VN1R3; -.
DR HGNC; HGNC:19867; VN1R3.
DR neXtProt; NX_Q9BXE9; -.
DR InParanoid; Q9BXE9; -.
DR OrthoDB; 1155990at2759; -.
DR PhylomeDB; Q9BXE9; -.
DR PathwayCommons; Q9BXE9; -.
DR GenomeRNAi; 317702; -.
DR Pharos; Q9BXE9; Tdark.
DR PRO; PR:Q9BXE9; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q9BXE9; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Vomeronasal type-1 receptor 3"
FT /id="PRO_0000070215"
FT TOPO_DOM 1..5
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..92
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..249
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 311 AA; 34713 MW; B310408A12160DBD CRC64;
MASKDFAIGM ILLSQIMVGF LGNFFLLYHY SFLCFTRGML QSTDLILKHL TIANSLVILS
KGIPQTMAAF GLKDSLSDIG CKFVFYVHRV GRAVCVGNAC LLSVFQVITI SPSEFRWAEL
KLHAHKYIRS FILVLCWILN TLVNITVLLH VTGKWNSINS TKTNDYGYCS GGSRSRIPHS
LHIVLLSSLD VLCLGLMTLA SGSMVFILHR HKQQVQHIHG TNLSARSSPE SRVTQSILVL
VSTLCYFTRS PPSLHMSLFP NPSWWLLNTS ALITACFPMV SPFVLMSRHP RIPRLGSACC
GRNPQFPKLV R
