VN1R4_HUMAN
ID VN1R4_HUMAN Reviewed; 301 AA.
AC Q7Z5H5; Q2M3E2; Q7Z5H6; Q7Z5H7; Q8TDU2;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Vomeronasal type-1 receptor 4;
DE AltName: Full=G-protein coupled receptor GPCR27;
DE Short=hGPCR27;
DE AltName: Full=V1r-like receptor 4;
GN Name=VN1R4; Synonyms=V1RL4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12123587; DOI=10.1016/s0960-9822(02)00909-0;
RA Rodriguez I., Mombaerts P.;
RT "Novel human vomeronasal receptor-like genes reveal species-specific
RT families.";
RL Curr. Biol. 12:R409-R411(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-52; LEU-58 AND ASN-220.
RX PubMed=12826614; DOI=10.1073/pnas.1331721100;
RA Zhang J., Webb D.M.;
RT "Evolutionary deterioration of the vomeronasal pheromone transduction
RT pathway in catarrhine primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative pheromone receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: Various VN1R4 alleles are known. The sequence shown is
CC that of allele VN1R4*1. {ECO:0000269|PubMed:12826614}.
CC -!- MISCELLANEOUS: The chimpanzee and gorilla orthologous proteins do not
CC exist, their genes are pseudogenes.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of
CC August 2005;
CC URL="https://web.expasy.org/spotlight/back_issues/061";
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DR EMBL; AY114733; AAM66754.1; -; Genomic_DNA.
DR EMBL; AY312485; AAP85618.1; -; Genomic_DNA.
DR EMBL; AY312486; AAP85619.1; -; Genomic_DNA.
DR EMBL; AY312487; AAP85620.1; -; Genomic_DNA.
DR EMBL; AY312488; AAP85621.1; -; Genomic_DNA.
DR EMBL; AB083609; BAB89322.1; -; Genomic_DNA.
DR EMBL; BC104935; AAI04936.1; -; mRNA.
DR EMBL; BC104939; AAI04940.1; -; mRNA.
DR CCDS; CCDS33099.1; -.
DR RefSeq; NP_776256.2; NM_173857.2.
DR RefSeq; XP_011525187.1; XM_011526885.1.
DR AlphaFoldDB; Q7Z5H5; -.
DR SMR; Q7Z5H5; -.
DR BioGRID; 130445; 3.
DR STRING; 9606.ENSP00000310856; -.
DR GlyGen; Q7Z5H5; 2 sites.
DR PhosphoSitePlus; Q7Z5H5; -.
DR BioMuta; VN1R4; -.
DR DMDM; 68566197; -.
DR PaxDb; Q7Z5H5; -.
DR PeptideAtlas; Q7Z5H5; -.
DR PRIDE; Q7Z5H5; -.
DR Antibodypedia; 49778; 125 antibodies from 24 providers.
DR DNASU; 317703; -.
DR Ensembl; ENST00000311170.5; ENSP00000310856.4; ENSG00000228567.3.
DR GeneID; 317703; -.
DR KEGG; hsa:317703; -.
DR UCSC; uc010ydu.3; human.
DR CTD; 317703; -.
DR DisGeNET; 317703; -.
DR GeneCards; VN1R4; -.
DR HGNC; HGNC:19871; VN1R4.
DR HPA; ENSG00000228567; Not detected.
DR neXtProt; NX_Q7Z5H5; -.
DR PharmGKB; PA134985458; -.
DR VEuPathDB; HostDB:ENSG00000228567; -.
DR eggNOG; ENOG502RD1P; Eukaryota.
DR HOGENOM; CLU_058641_1_0_1; -.
DR InParanoid; Q7Z5H5; -.
DR OrthoDB; 951034at2759; -.
DR PhylomeDB; Q7Z5H5; -.
DR PathwayCommons; Q7Z5H5; -.
DR BioGRID-ORCS; 317703; 7 hits in 1024 CRISPR screens.
DR GeneWiki; VN1R4; -.
DR GenomeRNAi; 317703; -.
DR Pharos; Q7Z5H5; Tdark.
DR PRO; PR:Q7Z5H5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q7Z5H5; protein.
DR Bgee; ENSG00000228567; Expressed in testis.
DR Genevisible; Q7Z5H5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..301
FT /note="Vomeronasal type-1 receptor 4"
FT /id="PRO_0000070217"
FT TOPO_DOM 1..5
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..48
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..301
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 52
FT /note="A -> V (in allele VN1R4*3; dbSNP:rs74429916)"
FT /evidence="ECO:0000269|PubMed:12826614"
FT /id="VAR_022799"
FT VARIANT 58
FT /note="R -> L (in allele VN1R4*4; dbSNP:rs140031028)"
FT /evidence="ECO:0000269|PubMed:12826614"
FT /id="VAR_022800"
FT VARIANT 220
FT /note="D -> N (in allele VN1R4*2 and allele VN1R4*3;
FT dbSNP:rs12977715)"
FT /evidence="ECO:0000269|PubMed:12826614"
FT /id="VAR_022801"
SQ SEQUENCE 301 AA; 33557 MW; AB7F9792957BFCA6 CRC64;
MASRYVAVGM ILSQTVVGVL GSFSVLLHYL SFYCTGCRLR STDLIVKHLI VANFLALRCK
GVPQTMAAFG VRYFLNALGC KLVFYLHRVG RGVSIGTTCL LSVFQVITVS SRKSRWAKLK
EKAPKHVGFS VLLCWIVCML VNIIFPMYVT GKWNYTNITV NEDLGYCSGG GNNKIAQTLR
AMLLSFPDVL CLGLMLWVSS SMVCILHRHK QRVQHIDRSD LSPRASPENR ATQSILILVS
TFVSSYTLSC LFQVCMALLD NPNSLLVNTS ALMSVCFPTL SPFVLMSCDP SVYRFCFAWK
R
