ID   VN1R4_PONPY             Reviewed;         301 AA.
AC   Q7YRP2;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Vomeronasal type-1 receptor 4;
DE   AltName: Full=V1r-like receptor 4;
GN   Name=VN1R4; Synonyms=V1RL4;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12826614; DOI=10.1073/pnas.1331721100;
RA   Zhang J., Webb D.M.;
RT   "Evolutionary deterioration of the vomeronasal pheromone transduction
RT   pathway in catarrhine primates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
CC   -!- FUNCTION: Putative pheromone receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY312473; AAP85610.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7YRP2; -.
DR   SMR; Q7YRP2; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR   GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR004072; Vmron_rcpt_1.
DR   PANTHER; PTHR24062; PTHR24062; 1.
DR   Pfam; PF03402; V1R; 1.
DR   PRINTS; PR01534; VOMERONASL1R.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Pheromone response; Receptor; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..301
FT                   /note="Vomeronasal type-1 receptor 4"
FT                   /id="PRO_0000070218"
FT   TOPO_DOM        1..15
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..48
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..88
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..107
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        108..126
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        148..185
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        235..255
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        256..264
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..301
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        154
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        157
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   301 AA;  33511 MW;  E20B37D7FE6B67DC CRC64;
     MASRYVAVGM MLSQTVVGVL GSFSLLLHYL SLHYIGCRLR SADLIVKHLI AASFLTLLCK
     GVPQTMAAFR VRYFLNAIGC KLVFYLHRVG RGVSTGTTCL LSVFQVITVS SRKSRWAKLK
     EKAPKHVGFS VLLCWILCML VNIIFPIYVT GKRNHTNITV NKDLGDCCGR GNNKIAQTLR
     AMLLSFPDVL CLGFMLWASS SMVCILHRHK QRVQHIHRSN LSPRASPENR ATQSILIPVS
     TFVSSYTLSC LLQVCMALLD NPNSLLVNTS ALMSACFPTL SPFVLMSCDP SVYRLCFAWK
     R