VN1R5_HUMAN
ID VN1R5_HUMAN Reviewed; 357 AA.
AC Q7Z5H4; A0AVG1; Q8NEU5; Q8TDU3;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Vomeronasal type-1 receptor 5;
DE AltName: Full=G-protein coupled receptor GPCR26;
DE Short=hGPCR26;
DE AltName: Full=V1r-like receptor 5;
GN Name=VN1R5; Synonyms=V1RL5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12123587; DOI=10.1016/s0960-9822(02)00909-0;
RA Rodriguez I., Mombaerts P.;
RT "Novel human vomeronasal receptor-like genes reveal species-specific
RT families.";
RL Curr. Biol. 12:R409-R411(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT CYS-350.
RX PubMed=12826614; DOI=10.1073/pnas.1331721100;
RA Zhang J., Webb D.M.;
RT "Evolutionary deterioration of the vomeronasal pheromone transduction
RT pathway in catarrhine primates.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative pheromone receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- POLYMORPHISM: There is an allele VN1R5*2 with a truncating mutation in
CC position 46. It was found with a frequency of about 32%.
CC {ECO:0000269|PubMed:12826614}.
CC -!- MISCELLANEOUS: The chimpanzee and orangutan orthologous proteins do not
CC exist, their genes are pseudogenes.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of
CC August 2005;
CC URL="https://web.expasy.org/spotlight/back_issues/061";
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DR EMBL; AY114735; AAM66756.1; -; Genomic_DNA.
DR EMBL; AY312489; AAP85622.1; -; Genomic_DNA.
DR EMBL; AY312490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY312491; AAP85623.1; -; Genomic_DNA.
DR EMBL; AB083608; BAB89321.1; -; Genomic_DNA.
DR EMBL; BC126341; AAI26342.1; -; mRNA.
DR EMBL; BC126367; AAI26368.1; -; mRNA.
DR CCDS; CCDS86062.1; -.
DR RefSeq; NP_776257.1; NM_173858.1.
DR AlphaFoldDB; Q7Z5H4; -.
DR BioGRID; 130446; 2.
DR IntAct; Q7Z5H4; 2.
DR MINT; Q7Z5H4; -.
DR GlyGen; Q7Z5H4; 1 site.
DR iPTMnet; Q7Z5H4; -.
DR PhosphoSitePlus; Q7Z5H4; -.
DR BioMuta; VN1R5; -.
DR MassIVE; Q7Z5H4; -.
DR PRIDE; Q7Z5H4; -.
DR ProteomicsDB; 69293; -.
DR TopDownProteomics; Q7Z5H4; -.
DR DNASU; 317705; -.
DR GeneID; 317705; -.
DR KEGG; hsa:317705; -.
DR CTD; 317705; -.
DR DisGeNET; 317705; -.
DR GeneCards; VN1R5; -.
DR HGNC; HGNC:19870; VN1R5.
DR neXtProt; NX_Q7Z5H4; -.
DR PharmGKB; PA134993066; -.
DR InParanoid; Q7Z5H4; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q7Z5H4; -.
DR PathwayCommons; Q7Z5H4; -.
DR SignaLink; Q7Z5H4; -.
DR BioGRID-ORCS; 317705; 5 hits in 194 CRISPR screens.
DR GeneWiki; VN1R5; -.
DR GenomeRNAi; 317705; -.
DR Pharos; Q7Z5H4; Tdark.
DR PRO; PR:Q7Z5H4; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q7Z5H4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 2.
DR PRINTS; PR01534; VOMERONASL1R.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..357
FT /note="Vomeronasal type-1 receptor 5"
FT /id="PRO_0000070220"
FT TOPO_DOM 1..3
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 4..24
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..300
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 322..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 297
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 350
FT /note="R -> C (in allele VN1R5*3; dbSNP:rs41308154)"
FT /evidence="ECO:0000269|PubMed:12826614"
FT /id="VAR_022802"
FT CONFLICT 66
FT /note="F -> Y (in Ref. 3; BAB89321)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 40779 MW; 0E01BA2B43D5F2FE CRC64;
MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY PQASFGISAN
TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI LVSLDFFGSQ NTQDDLRYKV
IVFLNKVMRG LSICTPCLLS VLQAIISPSI FSLAKLKHPS ASHILGFFLF SWVLNMFIGV
IFCCTLRLPP VKRGQSSVCH TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD
YFIQTIRGYL SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL
LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR QCGSTKK
