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VN1R5_HUMAN
ID   VN1R5_HUMAN             Reviewed;         357 AA.
AC   Q7Z5H4; A0AVG1; Q8NEU5; Q8TDU3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 2.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Vomeronasal type-1 receptor 5;
DE   AltName: Full=G-protein coupled receptor GPCR26;
DE            Short=hGPCR26;
DE   AltName: Full=V1r-like receptor 5;
GN   Name=VN1R5; Synonyms=V1RL5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12123587; DOI=10.1016/s0960-9822(02)00909-0;
RA   Rodriguez I., Mombaerts P.;
RT   "Novel human vomeronasal receptor-like genes reveal species-specific
RT   families.";
RL   Curr. Biol. 12:R409-R411(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT CYS-350.
RX   PubMed=12826614; DOI=10.1073/pnas.1331721100;
RA   Zhang J., Webb D.M.;
RT   "Evolutionary deterioration of the vomeronasal pheromone transduction
RT   pathway in catarrhine primates.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:8337-8341(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA   Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT   "Identification of G protein-coupled receptor genes from the human genome
RT   sequence.";
RL   FEBS Lett. 520:97-101(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Putative pheromone receptor.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- POLYMORPHISM: There is an allele VN1R5*2 with a truncating mutation in
CC       position 46. It was found with a frequency of about 32%.
CC       {ECO:0000269|PubMed:12826614}.
CC   -!- MISCELLANEOUS: The chimpanzee and orangutan orthologous proteins do not
CC       exist, their genes are pseudogenes.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=No one nose - Issue 61 of
CC       August 2005;
CC       URL="https://web.expasy.org/spotlight/back_issues/061";
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DR   EMBL; AY114735; AAM66756.1; -; Genomic_DNA.
DR   EMBL; AY312489; AAP85622.1; -; Genomic_DNA.
DR   EMBL; AY312490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY312491; AAP85623.1; -; Genomic_DNA.
DR   EMBL; AB083608; BAB89321.1; -; Genomic_DNA.
DR   EMBL; BC126341; AAI26342.1; -; mRNA.
DR   EMBL; BC126367; AAI26368.1; -; mRNA.
DR   CCDS; CCDS86062.1; -.
DR   RefSeq; NP_776257.1; NM_173858.1.
DR   AlphaFoldDB; Q7Z5H4; -.
DR   BioGRID; 130446; 2.
DR   IntAct; Q7Z5H4; 2.
DR   MINT; Q7Z5H4; -.
DR   GlyGen; Q7Z5H4; 1 site.
DR   iPTMnet; Q7Z5H4; -.
DR   PhosphoSitePlus; Q7Z5H4; -.
DR   BioMuta; VN1R5; -.
DR   MassIVE; Q7Z5H4; -.
DR   PRIDE; Q7Z5H4; -.
DR   ProteomicsDB; 69293; -.
DR   TopDownProteomics; Q7Z5H4; -.
DR   DNASU; 317705; -.
DR   GeneID; 317705; -.
DR   KEGG; hsa:317705; -.
DR   CTD; 317705; -.
DR   DisGeNET; 317705; -.
DR   GeneCards; VN1R5; -.
DR   HGNC; HGNC:19870; VN1R5.
DR   neXtProt; NX_Q7Z5H4; -.
DR   PharmGKB; PA134993066; -.
DR   InParanoid; Q7Z5H4; -.
DR   OrthoDB; 1390012at2759; -.
DR   PhylomeDB; Q7Z5H4; -.
DR   PathwayCommons; Q7Z5H4; -.
DR   SignaLink; Q7Z5H4; -.
DR   BioGRID-ORCS; 317705; 5 hits in 194 CRISPR screens.
DR   GeneWiki; VN1R5; -.
DR   GenomeRNAi; 317705; -.
DR   Pharos; Q7Z5H4; Tdark.
DR   PRO; PR:Q7Z5H4; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q7Z5H4; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR   GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR   InterPro; IPR004072; Vmron_rcpt_1.
DR   PANTHER; PTHR24062; PTHR24062; 1.
DR   Pfam; PF03402; V1R; 2.
DR   PRINTS; PR01534; VOMERONASL1R.
PE   2: Evidence at transcript level;
KW   Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW   Pheromone response; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..357
FT                   /note="Vomeronasal type-1 receptor 5"
FT                   /id="PRO_0000070220"
FT   TOPO_DOM        1..3
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..24
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..130
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        152..163
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        185..269
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..290
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        291..300
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        322..357
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        297
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         350
FT                   /note="R -> C (in allele VN1R5*3; dbSNP:rs41308154)"
FT                   /evidence="ECO:0000269|PubMed:12826614"
FT                   /id="VAR_022802"
FT   CONFLICT        66
FT                   /note="F -> Y (in Ref. 3; BAB89321)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   357 AA;  40779 MW;  0E01BA2B43D5F2FE CRC64;
     MLKLVIIENM AEIMLFSLDL LLFSTDILCF NFPSKMIKLP GFITIQIFFY PQASFGISAN
     TILLLFHIFT FVFSHRSKSI DMIISHLSLI HILLLFTQAI LVSLDFFGSQ NTQDDLRYKV
     IVFLNKVMRG LSICTPCLLS VLQAIISPSI FSLAKLKHPS ASHILGFFLF SWVLNMFIGV
     IFCCTLRLPP VKRGQSSVCH TALFLFAHEL HPQETVFHTN DFEGCHLYRV HGPLKRLHGD
     YFIQTIRGYL SAFTQPACPR VSPVKRASQA ILLLVSFVFT YWVDFTFSFS GGVTWINDSL
     LVWLQVIVAN SYAAISPLML IYADNQIFKT LQMLWFKYLS PPKLMLKFNR QCGSTKK
 
 
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