VNN3_MOUSE
ID VNN3_MOUSE Reviewed; 500 AA.
AC Q9QZ25; E9QMT9;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Vascular non-inflammatory molecule 3;
DE Short=Vanin-3;
DE Flags: Precursor;
GN Name=Vnn3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=10501839; DOI=10.1007/s002510050580;
RA Granjeaud S., Naquet P., Galland F.;
RT "An ESTs description of the new vanin gene family conserved from fly to
RT human.";
RL Immunogenetics 49:964-972(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11491533; DOI=10.1007/s002510100327;
RA Martin F., Malergue F., Pitari G., Philippe J.M., Philips S., Chabret C.,
RA Granjeaud S., Mattei M.G., Mungall A.J., Naquet P., Galland F.;
RT "Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode
RT isoforms of pantetheinase ectoenzymes.";
RL Immunogenetics 53:296-306(2001).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}. Note=According to PubMed:11491533, secreted.
CC {ECO:0000269|PubMed:11491533}.
CC -!- TISSUE SPECIFICITY: Ubiquitous with higher expression in liver.
CC {ECO:0000269|PubMed:11491533}.
CC -!- SIMILARITY: Belongs to the carbon-nitrogen hydrolase superfamily.
CC BTD/VNN family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB59323.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ132103; CAB59323.1; ALT_INIT; mRNA.
DR EMBL; AC153973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS23734.1; -.
DR RefSeq; NP_036109.3; NM_011979.2.
DR AlphaFoldDB; Q9QZ25; -.
DR SMR; Q9QZ25; -.
DR STRING; 10090.ENSMUSP00000020190; -.
DR GlyGen; Q9QZ25; 5 sites.
DR iPTMnet; Q9QZ25; -.
DR PhosphoSitePlus; Q9QZ25; -.
DR CPTAC; non-CPTAC-4002; -.
DR MaxQB; Q9QZ25; -.
DR PaxDb; Q9QZ25; -.
DR PRIDE; Q9QZ25; -.
DR ProteomicsDB; 297576; -.
DR Antibodypedia; 2278; 83 antibodies from 21 providers.
DR DNASU; 26464; -.
DR Ensembl; ENSMUST00000020190; ENSMUSP00000020190; ENSMUSG00000020010.
DR GeneID; 26464; -.
DR KEGG; mmu:26464; -.
DR UCSC; uc007eqb.2; mouse.
DR CTD; 26464; -.
DR MGI; MGI:1347055; Vnn3.
DR VEuPathDB; HostDB:ENSMUSG00000020010; -.
DR eggNOG; KOG0806; Eukaryota.
DR GeneTree; ENSGT00390000013823; -.
DR HOGENOM; CLU_033209_2_0_1; -.
DR InParanoid; Q9QZ25; -.
DR OMA; AVKVYHY; -.
DR OrthoDB; 1276751at2759; -.
DR PhylomeDB; Q9QZ25; -.
DR TreeFam; TF323645; -.
DR BioGRID-ORCS; 26464; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9QZ25; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9QZ25; protein.
DR Bgee; ENSMUSG00000020010; Expressed in granulocyte and 33 other tissues.
DR Genevisible; Q9QZ25; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017159; F:pantetheine hydrolase activity; IDA:BHF-UCL.
DR GO; GO:0015939; P:pantothenate metabolic process; IDA:BHF-UCL.
DR CDD; cd07567; biotinidase_like; 1.
DR Gene3D; 3.60.110.10; -; 1.
DR InterPro; IPR012101; Biotinidase-like_euk.
DR InterPro; IPR040154; Biotinidase/VNN.
DR InterPro; IPR003010; C-N_Hydrolase.
DR InterPro; IPR036526; C-N_Hydrolase_sf.
DR InterPro; IPR043957; Vanin_C.
DR PANTHER; PTHR10609; PTHR10609; 1.
DR Pfam; PF00795; CN_hydrolase; 1.
DR Pfam; PF19018; Vanin_C; 1.
DR PIRSF; PIRSF011861; Biotinidase; 1.
DR SUPFAM; SSF56317; SSF56317; 1.
DR PROSITE; PS50263; CN_HYDROLASE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Hydrolase; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..469
FT /note="Vascular non-inflammatory molecule 3"
FT /id="PRO_0000019722"
FT PROPEP 470..500
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000019723"
FT DOMAIN 31..307
FT /note="CN hydrolase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00054"
FT LIPID 469
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 147
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 270
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 319
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 357
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 393
FT /note="V -> G (in Ref. 1; CAB59323)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 500 AA; 56305 MW; 46F29333292C5AED CRC64;
MASLHFPQWA VSFVFFAQAV GSMDTFIAAV YEHAVILPNK TESPVSTEEA LLLINKNIDI
LESAIKLAAR QGAHIIVTPE DGIYGWIFTR ETIYPYLEDI PDPEVNWIPC RDPRRFGYTP
VQERLSCLAK ENSIYIMANI GDKKPCNATD PHCPPDGRYQ YNTNVVFDSK GRLTARYHKY
NLFEPEIQFD FPKDSELVTF DTPFGKFGIF TCFDIFSYDP AVVVVKDTQV DSVLLPTAWY
NTLPLLSAVP FHSVWARAMG VNVLAANTHN TSMHMTGSGI YSPEAVRVYH YDMETESGQL
LLSELRSRPR QHATPAEVNW SAYARTVKPF SSGQADFPGK IYFDEFSFTK LTGSAGNYTV
CQKDLCCHLT YKMSESRMDE VYVLGAFDGL HTVEGQYYLQ ICTLLKCQTT NSRTCGEPVG
SAFTKFEEFS LSGTFRTKYV FPQIVLSGSQ LALERYYEVS RDGRLRSRGG APLPILVMAL
YGRVFERDPP RLGQGPGKLQ
