ID   VNP2_DENAN              Reviewed;          53 AA.
AC   Q8QGP7;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Natriuretic peptide DNP-2;
DE   Flags: Precursor;
OS   Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis.
OX   NCBI_TaxID=8618;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Woodard G.E., Brown J.;
RT   "Nucleotide sequence of Dendroaspis natriuretic peptide from first amino
RT   acid to 3' polyadenylation tail.";
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Snake venom natriuretic peptide that exhibits hypotensive and
CC       vasodepressor activity. Acts by activating natriuretic receptors (NPR1
CC       and/or NPR2 and/or NPR3) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; AF344184; AAL99383.1; -; mRNA.
DR   AlphaFoldDB; Q8QGP7; -.
DR   SMR; Q8QGP7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hypotensive agent; Secreted; Toxin; Vasoactive;
KW   Vasodilator.
FT   PEPTIDE         1..38
FT                   /note="Natriuretic peptide DNP-2"
FT                   /id="PRO_0000403795"
FT   PROPEP          39..53
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403796"
FT   DISULFID        7..23
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   53 AA;  5906 MW;  A83781294E08ED26 CRC64;
     EVKYDPCFGH KIDRINHVSN LGCPSLRDPR PTAPAALRII RDLHPDSKQS QAA