ID   VNP31_BUNFL             Reviewed;         148 AA.
AC   D5J9S0;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Natriuretic peptide BF131;
DE   Flags: Precursor;
OS   Bungarus flaviceps flaviceps (Red-headed krait).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Bungarinae; Bungarus.
OX   NCBI_TaxID=8615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=20350308; DOI=10.1186/1471-2199-11-24;
RA   Siang A.S., Doley R., Vonk F.J., Kini R.M.;
RT   "Transcriptomic analysis of the venom gland of the red-headed krait
RT   (Bungarus flaviceps) using expressed sequence tags.";
RL   BMC Mol. Biol. 11:24-24(2010).
CC   -!- FUNCTION: Natriuretic peptide that dose-dependently induces the rapid
CC       relaxation of rat aortic strips phenylephrine-precontracted. Acts by
CC       stimulating cGMP production in a dose-dependent manner. Does not
CC       inhibits platelet aggregation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; GU190821; ADF50041.1; -; mRNA.
DR   AlphaFoldDB; D5J9S0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR000663; Natr_peptide.
DR   Pfam; PF00212; ANP; 1.
DR   SMART; SM00183; NAT_PEP; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hypotensive agent; Secreted; Signal; Toxin; Vasoactive;
KW   Vasodilator.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   PROPEP          28..83
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403797"
FT   PEPTIDE         84..133
FT                   /note="Natriuretic peptide BF131"
FT                   /id="PRO_0000403798"
FT   PROPEP          134..148
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403799"
FT   REGION          54..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        62..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        94..110
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   148 AA;  15748 MW;  BA3C3D8A0358772A CRC64;
     MVGPSRLAGG GLLLLLLLAL LPLALDGKPA PPPQALPKDP AAASAAERIM RALLPDSKSS
     RPATDRMVHP EHQAGGGDTR RLQEPAKKGL LISCFDRRID RISHTSDMGC RHRKDPPRAP
     PAAPSAAPLA VTWLIRDLRA DSKQSRAA