ID   VNP_MICFL               Reviewed;         139 AA.
AC   B8K1V9;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Natriuretic peptide Mf-NP;
DE   Flags: Precursor;
OS   Micrurus fulvius (Eastern coral snake) (Coluber fulvius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX   NCBI_TaxID=8637;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Subsp. fulvius; TISSUE=Venom gland;
RA   Tsai I.-H., Tsai H.-Y., Chen H.-S., Wang Y.-M.;
RT   "Characterization and sequence analyses of venom proteins of Micrurus f.
RT   fulvius (eastern coral snake) including a myoglobinuria-inducing
RT   phospholipase A2.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Snake venom natriuretic peptide that exhibits hypotensive and
CC       vasodepressor activity. Acts by activating natriuretic receptors (NPR1
CC       and/or NPR2 and/or NPR3) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; DQ137797; AAZ39879.1; -; mRNA.
DR   AlphaFoldDB; B8K1V9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR002406; C_natriurtcpep.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00713; CNATPEPTIDE.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hypotensive agent; Secreted; Signal; Toxin; Vasoactive;
KW   Vasodilator.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..75
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403792"
FT   PEPTIDE         76..116
FT                   /note="Natriuretic peptide Mf-NP"
FT                   /id="PRO_0000403793"
FT   PROPEP          117..139
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403794"
FT   DISULFID        86..102
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   139 AA;  14646 MW;  91E0AA8CFDA2E759 CRC64;
     MVGLSRLTGG GLLLVLALLP LALDGKPLEE APTAPSRIIP FSRPVRKESQ AVLDPMVHPE
     RPAGSGDDGD LSRLEGLAKE ALGDGCFGLK LDRIGTSSGL GCNPKRPDPA PTALARIIPF
     SRPVRKESRA ALDRMQHPG