ID   VNP_NAJAT               Reviewed;         165 AA.
AC   D9IX97;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Natriuretic peptide Na-NP;
DE   Flags: Precursor;
OS   Naja atra (Chinese cobra).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
OX   NCBI_TaxID=8656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 84-128, FUNCTION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=21050868; DOI=10.1016/j.toxicon.2010.10.014;
RA   Zhang Y., Wu J., Yu G., Chen Z., Zhou X., Zhu S., Li R., Zhang Y., Lu Q.;
RT   "A novel natriuretic peptide from the cobra venom.";
RL   Toxicon 57:134-140(2011).
CC   -!- FUNCTION: Natriuretic peptide that dose-dependently induces the rapid
CC       relaxation of rat aortic strips phenylephrine-precontracted. Acts by
CC       stimulating cGMP production in a dose-dependent manner (by probably
CC       activating NPR1 and/or NPR2). May also show potent hypotensive effects.
CC       {ECO:0000269|PubMed:21050868}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=4618.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:21050868};
CC   -!- MISCELLANEOUS: Does not inhibits platelet aggregation.
CC       {ECO:0000305|PubMed:21050868}.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; HM217215; ADK12001.1; -; mRNA.
DR   AlphaFoldDB; D9IX97; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044551; P:envenomation resulting in vasodilation in another organism; IDA:UniProtKB.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002408; Natriuretic_peptide_brain.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00712; BNATPEPTIDE.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hypotensive agent; Secreted;
KW   Signal; Toxin; Vasoactive; Vasodilator.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..83
FT                   /evidence="ECO:0000269|PubMed:21050868"
FT                   /id="PRO_0000403800"
FT   PEPTIDE         84..128
FT                   /note="Natriuretic peptide Na-NP"
FT                   /id="PRO_0000403801"
FT   PROPEP          129..165
FT                   /id="PRO_0000403802"
FT   REGION          56..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          135..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        94..110
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   165 AA;  17345 MW;  2E5B1B1989376ADB CRC64;
     MVGLSRLAGG GLLLVLALLP LALDGKPAPE ALHKPPTGLR TSLAALRILG YLRPDSKQSR
     AARDRMLHPE QQVGGGGDSR PLQDETNKGK GSSCFGQKID RIGSMSGMGC RTQGKPPPAL
     PTAPAALRIL EYLRPDSKRS RATRDRMLHP EQQVGGGGGG GSRVI