ID   VNP_PHIOL               Reviewed;         164 AA.
AC   Q09GK2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=C-type natriuretic peptide;
DE            Short=CNP;
DE   Flags: Precursor;
OS   Philodryas olfersii (Green snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Dipsadidae; Philodryas.
OX   NCBI_TaxID=120305;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABI74693.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Venom gland {ECO:0000269|PubMed:16857193};
RX   PubMed=16857193; DOI=10.1016/j.febslet.2006.07.010;
RA   Ching A.T.C., Rocha M.M.T., Paes Leme A.F., Pimenta D.C., Furtado M.F.D.,
RA   Serrano S.M.T., Ho P.L., Junqueira-de-Azevedo I.L.M.;
RT   "Some aspects of the venom proteome of the Colubridae snake Philodryas
RT   olfersii revealed from a Duvernoy's (venom) gland transcriptome.";
RL   FEBS Lett. 580:4417-4422(2006).
RN   [2]
RP   ERRATUM OF PUBMED:16857193.
RA   Ching A.T.C., Rocha M.M.T., Paes Leme A.F., Pimenta D.C., Furtado M.F.D.,
RA   Serrano S.M.T., Ho P.L., Junqueira-de-Azevedo I.L.M.;
RL   FEBS Lett. 580:5122-5123(2006).
CC   -!- FUNCTION: Snake venom natriuretic peptide that exhibits hypotensive and
CC       vasodepressor activity. Acts by activating natriuretic receptors (NPR1
CC       and/or NPR2 and/or NPR3) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16857193}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:16857193}.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000255}.
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DR   EMBL; DQ912656; ABI74693.1; -; mRNA.
DR   AlphaFoldDB; Q09GK2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Hypotensive agent; Secreted; Signal;
KW   Toxin; Vasoactive; Vasodilator.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..140
FT                   /evidence="ECO:0000250|UniProtKB:Q6LEM5, ECO:0000255"
FT                   /id="PRO_0000315892"
FT   PEPTIDE         143..164
FT                   /note="C-type natriuretic peptide"
FT                   /evidence="ECO:0000250|UniProtKB:Q6LEM5"
FT                   /id="PRO_0000315893"
FT   REGION          24..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   164 AA;  15855 MW;  642B34750F6560D1 CRC64;
     MVASRLAAGG LLLLALLALA LDGKPAPPQP LRKAPAGGTT AWRRELTEQP EGASRPAAGG
     GGGGGRSGSK AANAAPTAPK SKGGAAAAAA AAARLMRDLR PDSKQARAAW GRMVHPEHHA
     GGGGGGGGGG GASRRLKGVA KKGLGKGCFG LKLDRIGSMS GLGC