ID   VNP_RHATT               Reviewed;         161 AA.
AC   D1MZV3;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Natriuretic peptide;
DE   Flags: Precursor;
OS   Rhabdophis tigrinus tigrinus (Tiger keelback snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Colubridae; Natricinae; Rhabdophis.
OX   NCBI_TaxID=193080;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Fujisawa D., Yamazaki Y., Morita T.;
RT   "Transcriptomic analysis of Duvernoy's gland of Colubridae Yamakagashi
RT   snake (Rhabdophis tigrinus tigrinus): exploring unidentified proteins and
RT   peptides.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Snake venom natriuretic peptide that exhibits hypotensive and
CC       vasodepressor activity. Acts by activating natriuretic receptors (NPR1
CC       and/or NPR2 and/or NPR3) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; AB539054; BAI59771.1; -; mRNA.
DR   AlphaFoldDB; D1MZV3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00710; NATPEPTIDES.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hypotensive agent; Secreted; Signal; Toxin; Vasoactive;
KW   Vasodilator.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..134
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403803"
FT   PEPTIDE         135..161
FT                   /note="Natriuretic peptide"
FT                   /id="PRO_0000403804"
FT   REGION          19..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        145..161
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   161 AA;  15932 MW;  28426FD4583BE2BC CRC64;
     MFASRLAALG LLLLALVLDG KPAPPPQPLR KAPAGGTTAL QRQLTEQQQQ QQQAEGSSGP
     AAGGGGGRSG SKTANAAPTA PKSKGAAASA ASRLLRDLRP DGKQSRAAWG RMVHPEHHAG
     GGGGGGGGGS RRLKGLPKKG LGSGCFGLKL DRIGSMSGLG C