ID   VNP_VARVA               Reviewed;         125 AA.
AC   Q2XXL8;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Natriuretic peptide GNP1;
DE   Flags: Precursor;
OS   Varanus varius (Lace monitor).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX   NCBI_TaxID=8559;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=16292255; DOI=10.1038/nature04328;
RA   Fry B.G., Vidal N., Norman J.A., Vonk F.J., Scheib H., Ramjan S.F.R.,
RA   Kuruppu S., Fung K., Blair Hedges S., Richardson M.K., Hodgson W.C.,
RA   Ignjatovic V., Summerhayes R., Kochva E.;
RT   "Early evolution of the venom system in lizards and snakes.";
RL   Nature 439:584-588(2006).
CC   -!- FUNCTION: Exhibits natriuretic and vasodepressor activity. Acts by
CC       stimulating cGMP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the natriuretic peptide family. {ECO:0000305}.
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DR   EMBL; DQ139927; AAZ75633.1; -; mRNA.
DR   AlphaFoldDB; Q2XXL8; -.
DR   PRIDE; Q2XXL8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   InterPro; IPR000663; Natr_peptide.
DR   InterPro; IPR030480; Natr_peptide_CS.
DR   InterPro; IPR002408; Natriuretic_peptide_brain.
DR   Pfam; PF00212; ANP; 1.
DR   PRINTS; PR00712; BNATPEPTIDE.
DR   SMART; SM00183; NAT_PEP; 1.
DR   PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hypotensive agent;
KW   Secreted; Signal; Toxin; Vasoactive.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..85
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000342437"
FT   CHAIN           88..123
FT                   /note="Natriuretic peptide GNP1"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000342438"
FT   REGION          23..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        94..110
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   125 AA;  13329 MW;  525CAC910BB93F95 CRC64;
     MDPRLVRAGS LVLLLALLVQ DQGAAHPARA GQKYKPLIRR SEEDSQALGQ EGDVAARAAD
     EEEDAAGPGD ALRQPAFKTL LASREKRLQP EGSCFGQKMD RIGHVSGMGC NKFDPNKGSS
     STGKK