VNRL4_HUMAN
ID VNRL4_HUMAN Reviewed; 208 AA.
AC Q8TDU5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Putative vomeronasal receptor-like protein 4;
DE AltName: Full=G-protein coupled receptor GPCR23;
DE Short=hGPCR23;
GN Name=VN1R17P; Synonyms=VNRL4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
CC -!- FUNCTION: Putative pheromone receptor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in olfactory nerve.
CC {ECO:0000269|PubMed:12044878}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AB083605; BAB89318.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8TDU5; -.
DR SMR; Q8TDU5; -.
DR BioMuta; HGNC:37331; -.
DR DMDM; 74760485; -.
DR MassIVE; Q8TDU5; -.
DR PRIDE; Q8TDU5; -.
DR GeneCards; VN1R17P; -.
DR HGNC; HGNC:37331; VN1R17P.
DR neXtProt; NX_Q8TDU5; -.
DR InParanoid; Q8TDU5; -.
DR PhylomeDB; Q8TDU5; -.
DR Pharos; Q8TDU5; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8TDU5; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 5: Uncertain;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..208
FT /note="Putative vomeronasal receptor-like protein 4"
FT /id="PRO_0000325896"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..48
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 86..173
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 208 AA; 23857 MW; 2CEFB06635AABD91 CRC64;
MEMTKLFSYI VIKNVYYPQV SFGISANTFL LLFHIFTFAY THRLKPIDMT ISHLPLIHIL
LLFTQAILVS SDLFESWNIQ NNDLKCKIIT FLNRVMRGVS ICTTCLLSVL QAITISPSTS
FLEKFKHISA NHTLGFILFS WVLNMFITNN LLLFIVPTPN RIGASLLFVT EHCYVLPMSY
THRSLFFILM VLRDVIFIGL MVLSSGYG
