ID   VNS1_AQRVC              Reviewed;         742 AA.
AC   Q8JU59;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   23-FEB-2022, entry version 45.
DE   RecName: Full=Non-structural protein 1;
DE            Short=NS1;
GN   Name=S4;
OS   Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Aquareovirus.
OX   NCBI_TaxID=185783;
OH   NCBI_TaxID=28800; Notemigonus crysoleucas (Golden shiner) (Cyprinus crysoleucas).
OH   NCBI_TaxID=90988; Pimephales promelas (Fathead minnow).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=12124458; DOI=10.1099/0022-1317-83-8-1941;
RA   Attoui H., Fang Q., Mohd Jaafar F., Cantaloube J.F., Biagini P.,
RA   de Micco P., de Lamballerie X.;
RT   "Common evolutionary origin of aquareoviruses and orthoreoviruses revealed
RT   by genome characterization of Golden shiner reovirus, Grass carp reovirus,
RT   Striped bass reovirus and golden ide reovirus (genus Aquareovirus, family
RT   Reoviridae).";
RL   J. Gen. Virol. 83:1941-1951(2002).
CC   -!- FUNCTION: Non-structural protein with ssRNA-binding activity. Is
CC       probably involved in the formation of viral inclusions, where the
CC       assembly of cores and the replication of viral RNA are thought to occur
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aquareoviridae NS1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF403401; AAM92747.1; -; Genomic_RNA.
DR   RefSeq; NP_938063.1; NC_005169.1.
DR   GeneID; 2648332; -.
DR   KEGG; vg:2648332; -.
DR   Proteomes; UP000006713; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Coiled coil; Reference proteome; RNA-binding.
FT   CHAIN           1..742
FT                   /note="Non-structural protein 1"
FT                   /id="PRO_0000404174"
FT   REGION          14..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          635..700
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        230..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   742 AA;  79460 MW;  D9F7B5429E11A4D4 CRC64;
     MARRITLNSL KPLSAMSNHP SLTPTTTPTA ATASTSTAPS IDSSTAPSLP STFNQMIFEF
     NGVKYTGAPH AWMMPYRGFE QHMVNMVIET RPDATFSRFD DLLSAIVTAL AVNGITATTS
     LTDGELVLLR FADLATRHAS LPSPSPAISD WSQSVPGPLL DTLEYGAPLI PAEPTATPAP
     TPLAPADYPP PPPHVADPAV SHSLVALDVP DAALPSMPRA STSTASIPSL MSLPIASPPR
     SRSSTLSSST STSTPRLPGT VVPRRPSHIA DDETYNRSRA AYAMGVPAMS PMYCTGKERH
     FEQTFYSAYP HAANGVWTAY QHSIILIAAP TEDISLLTLH NVEREQSATE AYHLRALDGA
     TVARVAVFRL APTMTCHDVH AMMAGHNVVS ISGLAAAFMI RHKLTDGVFS KSFRRIVMGI
     DPVMMRHDPV PLHLFAILTD HRLDHAATHA VMSMRLALMQ IESASYQATK AWLRGHLPVT
     IFASATTDSS SDSIHATILE ADKGMRVADT PGSSTLRELE ASNTALQRQV IDMDVQINAL
     LRTISDLKSY TNHQQASHGY SIQQYLHSHT CVNTQELPLI QSVMGDQAAN AIQAMRTHAN
     EAARSALTDK VTAPLTAQLS DTMAHLHEAR AHNGDLTAQL AIAETDAMTA ANERDRACEL
     AVELESQLAT MQREYDQTTR ALLQDNEQLQ HSAATAEAAA VSAFRPTPPL TYGTAPSALP
     AVGPGLTVPL LAAAIDPASL LL