ID   VNS1_AQRVG              Reviewed;         735 AA.
AC   B2BNE2;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   23-FEB-2022, entry version 31.
DE   RecName: Full=Non-structural protein 1;
DE            Short=NS1;
DE   AltName: Full=NS73;
GN   Name=S4;
OS   Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Aquareovirus.
OX   NCBI_TaxID=648234;
OH   NCBI_TaxID=7959; Ctenopharyngodon idella (Grass carp) (Leuciscus idella).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=18191982; DOI=10.1016/j.virol.2007.12.006;
RA   Mohd Jaafar F., Goodwin A.E., Belhouchet M., Merry G., Fang Q.,
RA   Cantaloube J.F., Biagini P., de Micco P., Mertens P.P., Attoui H.;
RT   "Complete characterisation of the American grass carp reovirus genome
RT   (genus Aquareovirus: family Reoviridae) reveals an evolutionary link
RT   between aquareoviruses and coltiviruses.";
RL   Virology 373:310-321(2008).
CC   -!- FUNCTION: Non-structural protein with ssRNA-binding activity. Is
CC       probably involved in the formation of viral inclusions, where the
CC       assembly of cores and the replication of viral RNA are thought to occur
CC       (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aquareoviridae NS1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; EF589101; ABV01042.1; -; Genomic_RNA.
DR   RefSeq; YP_001837097.1; NC_010587.1.
DR   GeneID; 6218802; -.
DR   KEGG; vg:6218802; -.
DR   Proteomes; UP000001674; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..735
FT                   /note="Non-structural protein 1"
FT                   /id="PRO_0000404175"
FT   REGION          18..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        251..272
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   735 AA;  80384 MW;  35C992F60DC3A30F CRC64;
     MSRRFRLGDI RSTGVAEYAS TPVRADASPT TNPPPTAAPA SLTSTDSHTM APPNQLTFDL
     SGVIFTGSPP AWLLQYRGFE KHMVTMLMLK SGVRTYPRFD DFISALVSTM ALMGIVPQTS
     LTDGEVILMR YANAETLPEP EETTRQWGDS PEAELANEGY GNDEIDNTPQ LQAPLISGPP
     QTYAAAAAPP SLQQSTVPLI SATPSPALSR SSSVASLTSI PACSPAPSSL PSILTMQTRP
     PSPSSKSHQP RVTLPERRPT RRPEHIANDE DYNRSRAGYA QGKPSHSPMY GSGRESHFEE
     AFFAAYPHSV DGRWHKFSAS IVVLADPNED PALLTLHSLE REEGAQETYI MRTSAAFAVA
     RVRVMRLRPT MSVHDVHDML AGHPVVSITG RACAYMVRHK LTDGVFSKQF RRIVMGIDPV
     MIRHGTQALS LFAILTDHRL DHAHTHAAMS LRLAMQFVES PLYDAQRSWL KAHAPATIHC
     AATSDSNADS TLSAIYRSDS TPRDQPTPGD STISQLTASN QELQIQITAL TTTNNIQARA
     IAELKACVRP HSTDTHHALS KYALAHTCIN TQELPLLTSL LGEDTATAIQ TARERAKDIA
     KRTLTERVAE PLRVMNASLE AELTHERAHS SELRATLAIL ETDLNTAARE RDAHAHMITS
     LQSEITELRQ ERLTVITSER TDVALLEQRV TDAERHAVAQ HQSLPLLYGS VSLELPPSPT
     EDELLTSVAP ADLWD