ID   VNS1_MOUSE              Reviewed;         182 AA.
AC   Q62471;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2002, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Vomeronasal secretory protein 1;
DE   AltName: Full=Lipocalin-3;
DE   AltName: Full=Vomeronasal secretory protein I;
DE            Short=VNSP I;
DE   Flags: Precursor;
GN   Name=Lcn3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ddY;
RX   PubMed=7813422; DOI=10.1002/j.1460-2075.1994.tb06927.x;
RA   Miyawaki A., Matsushita F., Ryo Y., Mikoshiba K.;
RT   "Possible pheromone-carrier function of two lipocalin proteins in the
RT   vomeronasal organ.";
RL   EMBO J. 13:5835-5842(1994).
CC   -!- FUNCTION: Transport of lipophilic molecules, possible pheromone-
CC       carrier.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in vomeronasal and posterior
CC       glands of the nasal septum, the ducts of which open into the lumen of
CC       the vomeronasal organ.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA07581.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D38580; BAA07581.1; ALT_INIT; mRNA.
DR   CCDS; CCDS15790.1; -.
DR   PIR; S51802; S51802.
DR   RefSeq; NP_034824.1; NM_010694.1.
DR   AlphaFoldDB; Q62471; -.
DR   SMR; Q62471; -.
DR   STRING; 10090.ENSMUSP00000028304; -.
DR   GlyGen; Q62471; 1 site.
DR   PaxDb; Q62471; -.
DR   PRIDE; Q62471; -.
DR   ProteomicsDB; 297609; -.
DR   DNASU; 16820; -.
DR   Ensembl; ENSMUST00000239498; ENSMUSP00000159300; ENSMUSG00000026936.
DR   GeneID; 16820; -.
DR   KEGG; mmu:16820; -.
DR   CTD; 16820; -.
DR   MGI; MGI:102669; Lcn3.
DR   VEuPathDB; HostDB:ENSMUSG00000026936; -.
DR   eggNOG; ENOG502S22P; Eukaryota.
DR   GeneTree; ENSGT01050000244868; -.
DR   InParanoid; Q62471; -.
DR   OrthoDB; 1450978at2759; -.
DR   Reactome; R-MMU-804914; Transport of fatty acids.
DR   BioGRID-ORCS; 16820; 2 hits in 73 CRISPR screens.
DR   PRO; PR:Q62471; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q62471; protein.
DR   Bgee; ENSMUSG00000026936; Expressed in olfactory epithelium and 18 other tissues.
DR   ExpressionAtlas; Q62471; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0031404; F:chloride ion binding; ISO:MGI.
DR   GO; GO:0042802; F:identical protein binding; IPI:MGI.
DR   GO; GO:0005550; F:pheromone binding; IEA:UniProtKB-KW.
DR   GO; GO:0043621; F:protein self-association; IDA:MGI.
DR   GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; ISO:MGI.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002450; von_Ebner_gland.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01175; VNEBNERGLAND.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Pheromone-binding; Reference proteome;
KW   Secreted; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..182
FT                   /note="Vomeronasal secretory protein 1"
FT                   /id="PRO_0000017978"
FT   CARBOHYD        30
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        76..168
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   182 AA;  20626 MW;  46903612A91AE8DA CRC64;
     MRALLLIISF CLVAVLQAQD SSFLAFNNGN FSGKWFLKAL VSEDDIPINK VSPMLILVLN
     NGDIELSITH MIYDQCLEVT TILEKTDVPG QYLAFEGKTH LQVQLSSVKG HYMLYCDGEI
     EGMRFLMTQL IGRDPQENLE ALEEFKVFTQ IKGLVAENLV ILEQMEKCEP ESFYELPSRP
     SE