ID   VNS2_BTV10              Reviewed;         357 AA.
AC   P23065;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   02-JUN-2021, entry version 70.
DE   RecName: Full=Non-structural protein NS2;
GN   Name=Segment-8;
OS   Bluetongue virus 10 (isolate USA) (BTV 10).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10900;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2544660; DOI=10.1099/0022-1317-70-7-1677;
RA   Fukusho A., Yu Y., Yamaguchi S., Roy P.;
RT   "Completion of the sequence of bluetongue virus serotype 10 by the
RT   characterization of a structural protein, VP6, and a non-structural
RT   protein, NS2.";
RL   J. Gen. Virol. 70:1677-1689(1989).
CC   -!- FUNCTION: Single-stranded RNA-binding protein.
CC   -!- SIMILARITY: Belongs to the orbivirus non-structural protein NS2 family.
CC       {ECO:0000305}.
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DR   EMBL; D00500; BAA00392.1; -; Genomic_RNA.
DR   PIR; A32400; MNXRC3.
DR   PDB; 1UTY; X-ray; 2.40 A; A/B=1-177.
DR   PDBsum; 1UTY; -.
DR   SMR; P23065; -.
DR   EvolutionaryTrace; P23065; -.
DR   Proteomes; UP000007662; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007602; BTV_NS2.
DR   InterPro; IPR037194; NS2_N.
DR   Pfam; PF04514; BTV_NS2; 1.
DR   SUPFAM; SSF110132; SSF110132; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; RNA-binding.
FT   CHAIN           1..357
FT                   /note="Non-structural protein NS2"
FT                   /id="PRO_0000222675"
FT   REGION          169..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..191
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..246
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          10..15
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   HELIX           22..29
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   STRAND          33..42
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   STRAND          44..50
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   STRAND          56..59
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   STRAND          61..70
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   STRAND          73..79
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   STRAND          84..89
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   STRAND          97..100
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   STRAND          102..110
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   STRAND          113..123
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   STRAND          133..135
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   HELIX           138..140
FT                   /evidence="ECO:0007829|PDB:1UTY"
FT   HELIX           154..157
FT                   /evidence="ECO:0007829|PDB:1UTY"
SQ   SEQUENCE   357 AA;  40999 MW;  3484FD802F9327A1 CRC64;
     MEQKQRRFTK NIFVLDVTAK TLCGAIAKLS SQPYCQIKIG RVVAFKPVKN PEPKGYVLNV
     PGPGAYRIQD GQDIISLMLT PHGVEATTER WEEWKFEGVS VTPMATRVQY NGVMVDAEIK
     YCKGMGIVQP YMRNDFDRNE MPDLPGVMRS NYDIRELRQK IKNERESAPR LQVHSVAPRE
     ESRWMDDDEA KVDDEAKEIV PGTSGLEKLR EARSNVFKEV EAVINWNLDE RDEGDRDERG
     DEEQVKTLSD DDDQGEDASD DEHPKTHITK EYIEKVAKQI KLKDERFMSL SSAMPQASGG
     FDRMIVTKKL KWQNVPLYCF DESLKRYELQ CVGACERVAF VSKDMSLIIC RSAFRRL