ID   VNS2_EHDV2              Reviewed;         376 AA.
AC   P27280;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   02-JUN-2021, entry version 50.
DE   RecName: Full=Non-structural protein NS2;
GN   Name=Segment-8;
OS   Epizootic hemorrhagic disease virus 2 (strain Alberta) (EHDV-2).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10910;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9872; Odocoileus hemionus (Mule deer) (Cervus hemionus).
OH   NCBI_TaxID=9874; Odocoileus virginianus (White-tailed deer).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1656603; DOI=10.1016/0042-6822(91)90808-o;
RA   van Staden V., Theron J., Greyling B.J., Huismans H., Nel L.H.;
RT   "A comparison of the nucleotide sequences of cognate NS2 genes of three
RT   different orbiviruses.";
RL   Virology 185:500-504(1991).
CC   -!- FUNCTION: Single-stranded RNA-binding protein.
CC   -!- SIMILARITY: Belongs to the orbivirus non-structural protein NS2 family.
CC       {ECO:0000305}.
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DR   EMBL; M69091; AAA43001.1; -; Genomic_RNA.
DR   PIR; B40788; MNXREH.
DR   SMR; P27280; -.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR007602; BTV_NS2.
DR   InterPro; IPR037194; NS2_N.
DR   Pfam; PF04514; BTV_NS2; 1.
DR   SUPFAM; SSF110132; SSF110132; 1.
PE   3: Inferred from homology;
KW   RNA-binding.
FT   CHAIN           1..376
FT                   /note="Non-structural protein NS2"
FT                   /id="PRO_0000222679"
FT   REGION          163..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..189
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   376 AA;  43615 MW;  D54AA163075CB6EC CRC64;
     MEQKQRRFTK NVFVLDQKRK TICGQIAARQ SLPYCQIKIG RNFALRAVAT PEPKGYVLEI
     CDVGAYRIQD GNDVISLMIS ADGVEGTQER WEEWKFESDL MRTNGHSSKY KRSVGRREIK
     VSKGMGIVPP YTRNDFDRRE LPELPGVQRS KYDIRELRQK IREEREKGAV EQPHKPAFKT
     ERGMNRPDSD EDQNPAGGVV NDWTCETQKR DQEAERREAL EIRLADNDRE SKHSNWIVRG
     RGKILKEVKN SFRTQEVERK KSDMGEVIIE EDDEDSEEEE GARASYITSA YIERISRIRK
     IKDERLSMLA SMMPQQSGEY TTTLFIKKQK WDNVPLYLID EMQKKYELQS VGSCERVAFV
     SKGTNLIILP VASNPR