ID   VNS2_MOUSE              Reviewed;         185 AA.
AC   Q62472;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Vomeronasal secretory protein 2;
DE   AltName: Full=Lipocalin-4;
DE   AltName: Full=Vomeronasal secretory protein II;
DE            Short=VNSP II;
DE   Flags: Precursor;
GN   Name=Lcn4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ddY;
RX   PubMed=7813422; DOI=10.1002/j.1460-2075.1994.tb06927.x;
RA   Miyawaki A., Matsushita F., Ryo Y., Mikoshiba K.;
RT   "Possible pheromone-carrier function of two lipocalin proteins in the
RT   vomeronasal organ.";
RL   EMBO J. 13:5835-5842(1994).
CC   -!- FUNCTION: Transport of lipophilic molecules, possible pheromone-
CC       carrier.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in vomeronasal and posterior
CC       glands of the nasal septum, the ducts of which open into the lumen of
CC       the vomeronasal organ.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; D38581; BAA07582.1; -; mRNA.
DR   CCDS; CCDS15810.1; -.
DR   PIR; S51803; S51803.
DR   RefSeq; NP_034825.1; NM_010695.1.
DR   AlphaFoldDB; Q62472; -.
DR   SMR; Q62472; -.
DR   STRING; 10090.ENSMUSP00000028283; -.
DR   PaxDb; Q62472; -.
DR   PRIDE; Q62472; -.
DR   ProteomicsDB; 297610; -.
DR   DNASU; 16821; -.
DR   Ensembl; ENSMUST00000028283; ENSMUSP00000028283; ENSMUSG00000026919.
DR   GeneID; 16821; -.
DR   KEGG; mmu:16821; -.
DR   UCSC; uc008iwa.1; mouse.
DR   CTD; 16821; -.
DR   MGI; MGI:102668; Lcn4.
DR   VEuPathDB; HostDB:ENSMUSG00000026919; -.
DR   eggNOG; ENOG502S22P; Eukaryota.
DR   GeneTree; ENSGT01050000244868; -.
DR   HOGENOM; CLU_125034_0_0_1; -.
DR   InParanoid; Q62472; -.
DR   OMA; CIPIHDS; -.
DR   OrthoDB; 1450978at2759; -.
DR   PhylomeDB; Q62472; -.
DR   TreeFam; TF338197; -.
DR   BioGRID-ORCS; 16821; 2 hits in 73 CRISPR screens.
DR   PRO; PR:Q62472; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q62472; protein.
DR   Bgee; ENSMUSG00000026919; Expressed in olfactory epithelium and 11 other tissues.
DR   ExpressionAtlas; Q62472; baseline and differential.
DR   Genevisible; Q62472; MM.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005550; F:pheromone binding; IEA:UniProtKB-KW.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002450; von_Ebner_gland.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01175; VNEBNERGLAND.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Pheromone-binding; Reference proteome; Secreted; Signal;
KW   Transport.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..185
FT                   /note="Vomeronasal secretory protein 2"
FT                   /id="PRO_0000017979"
FT   DISULFID        80..172
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   185 AA;  21399 MW;  D93702D4FA5344AB CRC64;
     MKSLLLTVTL SSLVATLQTY DDLPFISEED KLSGVWFIKA TVSQRREVEG ETLVAFPIKF
     TCPEEGTLEL RHTLASKGEC INVGIRLQRT EEPGQYSAFW GHTLFYIYDL PVKDHYIIYC
     ESHPFQKISQ FGYLIGKYPE ENQDTLEVFK EFIQHKGFLQ EKIGVPEQRD RCIPIHDSAH
     QDHKC