ID   VNT1B_XENLA             Reviewed;         270 AA.
AC   Q9YH71;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Homeobox protein vent1B;
DE            Short=Xvent-1B;
GN   Name=vent1B; Synonyms=vent-1B {ECO:0000303|PubMed:10330491};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:CAA10305.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, AND
RP   INDUCTION.
RX   PubMed=10330491; DOI=10.1016/s0925-4773(98)00239-1;
RA   Rastegar S., Friedle H., Frommer G., Knoechel W.;
RT   "Transcriptional regulation of Xvent homeobox genes.";
RL   Mech. Dev. 81:139-149(1999).
CC   -!- FUNCTION: Probable transcription regulator. Acts in a ventral signaling
CC       pathway downstream of bmp4 and vent2B. {ECO:0000269|PubMed:10330491}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the ventral marginal zone of
CC       gastrulae. At the end of gastrulation, predominantly localized to the
CC       ventral region of the closing slit blastopore. At early tail bud stage,
CC       expression is maintained only in the forming proctodeum.
CC       {ECO:0000269|PubMed:10330491}.
CC   -!- INDUCTION: By vent2B downstream of bmp4. {ECO:0000269|PubMed:10330491}.
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DR   EMBL; AJ131094; CAA10305.1; -; Genomic_DNA.
DR   RefSeq; NP_001165683.1; NM_001172212.1.
DR   AlphaFoldDB; Q9YH71; -.
DR   SMR; Q9YH71; -.
DR   GeneID; 100337611; -.
DR   KEGG; xla:100337611; -.
DR   CTD; 100337611; -.
DR   Xenbase; XB-GENE-6464310; ventx1.1.S.
DR   OrthoDB; 1369499at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 100337611; Expressed in gastrula and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0030509; P:BMP signaling pathway; IMP:UniProtKB.
DR   GO; GO:0048264; P:determination of ventral identity; IMP:UniProtKB.
DR   GO; GO:0001707; P:mesoderm formation; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..270
FT                   /note="Homeobox protein vent1B"
FT                   /id="PRO_0000279723"
FT   DNA_BIND        128..187
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          17..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          88..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..115
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..130
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  30763 MW;  27F3B397B716AD70 CRC64;
     MVQQGFSIDL ILARSKEEAA DGKDSMSSRP HIPCAPQPLP PTKYAKEMPR RKDGQDVQEH
     TTSFQCSLGE QGNKLQYFSP SPAALHRTWG SSDEFSSAGS EDDTNECSPR PVRNFQDTDH
     NGKSTKSDRR LRTAFSPQQI SKLEQAFNKQ RYLGASERKK LATSLMLSEI QVKTWFQNRR
     MKLKRQIQDQ QHSLVPPPVC YPQTFPYYPG GFPVPLNSGS FYQPPALPFQ APQHSYIPDQ
     RFIPQPLPHH VRMSGALQEQ YPPLFRAQYI