VOME_MOUSE
ID VOME_MOUSE Reviewed; 591 AA.
AC Q80XI7; A2AJD0; Q5XK13; Q8CDY1;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Vomeromodulin {ECO:0000250|UniProtKB:Q63751};
DE AltName: Full=BPI fold-containing family B member 9A {ECO:0000312|MGI:MGI:3767993};
DE Flags: Precursor;
GN Name=Bpifb9a {ECO:0000312|MGI:MGI:3767993};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=20368189; DOI=10.1126/scitranslmed.3000284;
RA Shum A.K., DeVoss J., Tan C.L., Hou Y., Johannes K., O'Gorman C.S.,
RA Jones K.D., Sochett E.B., Fong L., Anderson M.S.;
RT "Identification of an autoantigen demonstrates a link between interstitial
RT lung disease and a defect in central tolerance.";
RL Sci. Transl. Med. 1:9RA20-9RA20(2009).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20368189}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80XI7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80XI7-2; Sequence=VSP_016661;
CC -!- TISSUE SPECIFICITY: Expressed in lung. Not detected in other tissues
CC tested (at protein level). {ECO:0000269|PubMed:20368189}.
CC -!- PTM: N-glycosylated. The N-glycans consist mainly of complex sialylated
CC and fucosylated biantennary structures. {ECO:0000250|UniProtKB:Q63751}.
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
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DR EMBL; AK029377; BAC26427.1; -; mRNA.
DR EMBL; AL732601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC047134; AAH47134.1; -; mRNA.
DR EMBL; BC080814; AAH80814.1; -; mRNA.
DR CCDS; CCDS50761.1; -. [Q80XI7-1]
DR RefSeq; NP_780376.2; NM_175167.3. [Q80XI7-1]
DR AlphaFoldDB; Q80XI7; -.
DR STRING; 10090.ENSMUSP00000086314; -.
DR GlyGen; Q80XI7; 2 sites.
DR iPTMnet; Q80XI7; -.
DR PhosphoSitePlus; Q80XI7; -.
DR MaxQB; Q80XI7; -.
DR PaxDb; Q80XI7; -.
DR PRIDE; Q80XI7; -.
DR ProteomicsDB; 300173; -. [Q80XI7-1]
DR ProteomicsDB; 300174; -. [Q80XI7-2]
DR DNASU; 71425; -.
DR Ensembl; ENSMUST00000088924; ENSMUSP00000086314; ENSMUSG00000067998. [Q80XI7-1]
DR GeneID; 71425; -.
DR KEGG; mmu:71425; -.
DR UCSC; uc008niz.1; mouse. [Q80XI7-1]
DR CTD; 71425; -.
DR MGI; MGI:3767993; Bpifb9a.
DR VEuPathDB; HostDB:ENSMUSG00000067998; -.
DR eggNOG; ENOG502TKQD; Eukaryota.
DR GeneTree; ENSGT00940000164301; -.
DR HOGENOM; CLU_032312_0_0_1; -.
DR InParanoid; Q80XI7; -.
DR OMA; DCKNSTG; -.
DR OrthoDB; 931706at2759; -.
DR PhylomeDB; Q80XI7; -.
DR TreeFam; TF338376; -.
DR BioGRID-ORCS; 71425; 0 hits in 39 CRISPR screens.
DR ChiTaRS; Bpifb9a; mouse.
DR PRO; PR:Q80XI7; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q80XI7; protein.
DR Bgee; ENSMUSG00000067998; Expressed in uterus and 8 other tissues.
DR Genevisible; Q80XI7; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007608; P:sensory perception of smell; IEA:InterPro.
DR InterPro; IPR017942; Lipid-bd_serum_glycop_N.
DR InterPro; IPR034433; Vomeromodulin.
DR PANTHER; PTHR40142; PTHR40142; 1.
DR Pfam; PF01273; LBP_BPI_CETP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal;
KW Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..591
FT /note="Vomeromodulin"
FT /id="PRO_0000045171"
FT REGION 151..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 421
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 516
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 528..591
FT /note="SEHSVVPPEAKEEVEGILSEVGKVAWSNFNETYKKMNIPVGVSSHTLKNSDV
FT KLMKSIDLQAAS -> YYNRACGTHSQDGIWGWGNISIITGIRN (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_016661"
SQ SEQUENCE 591 AA; 62448 MW; CEA0921C056A7B99 CRC64;
MWVLQALAIM LSIQAGTLDL VETPPVVGNL PVAMPVPLNL PVGGLSPPVL KGPVNHQMLP
PKRPVPPPKG GKCAPAARYF LSSDKLHDYL MSTLPPQIED MVKCDEVNLE GMLADVLNTV
ESSDLLSLLD GISLLKGGEG GGLGIGGLLG NEGNGDSSKP SSGSKATGGL GQLIPGGIPG
TEALGGLLNL GGDKSSGKGL LNGDGLSKIK KPLEDAVENV SGIKDAIQEK VNEVVPDGVK
EPLNDVLKMD IKDTLLELKV GQVTLDDMEI NMEANGMQVL SMLTATIDGK GVLGPVISLL
QFEAKMDVMT TIAVASNNTQ CVNLDAQDTH MHVKEMKIQL VETVTGKVPL PVPLPLDQII
PAIVTAKINE NLEKSNSCAI VLNDFNNCKN NTGLFSYQVN TARISPKGLV ILYCAKANIG
NKTVPVPGGR LPPDPKNASI AVTISSTTLK TLVKEVAKNS SVQMDGLEAQ ITHIAFASQE
NNTLRVVYKV DITKNGEHFA TGETKLFISH GSKISNSTLI PDVKLIRSEH SVVPPEAKEE
VEGILSEVGK VAWSNFNETY KKMNIPVGVS SHTLKNSDVK LMKSIDLQAA S
