ID   VOME_RAT                Reviewed;         589 AA.
AC   Q63751; Q05703;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2017, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Vomeromodulin {ECO:0000303|PubMed:1752363};
DE   AltName: Full=BPI fold-containing family B member 9 {ECO:0000250|UniProtKB:Q80XI7};
DE   Flags: Precursor;
GN   Name=Bpifb9 {ECO:0000250|UniProtKB:Q80XI7};
GN   Synonyms=RYF3 {ECO:0000303|PubMed:1915264};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Fischer {ECO:0000312|EMBL:CAA43066.1};
RC   TISSUE=Olfactory epithelium {ECO:0000312|EMBL:CAA43066.1};
RX   PubMed=1915264; DOI=10.1002/j.1460-2075.1991.tb07830.x;
RA   Dear T.N., Boehm T., Keverne E.B., Rabbitts T.H.;
RT   "Novel genes for potential ligand-binding proteins in subregions of the
RT   olfactory mucosa.";
RL   EMBO J. 10:2813-2819(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 493-589, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND GLYCOSYLATION.
RC   STRAIN=CD Charles River {ECO:0000312|EMBL:CAA45366.1};
RC   TISSUE=Nasal mucosa {ECO:0000312|EMBL:CAA45366.1};
RX   PubMed=1752363; DOI=10.1096/fasebj.5.14.1752363;
RA   Khew-Goodall Y.S., Grillo M., Getchell M.L., Danho W., Getchell T.V.,
RA   Margolis F.L.;
RT   "Vomeromodulin, a putative pheromone transporter: cloning,
RT   characterization, and cellular localization of a novel glycoprotein of
RT   lateral nasal gland.";
RL   FASEB J. 5:2976-2982(1991).
RN   [3]
RP   STRUCTURE OF CARBOHYDRATES.
RX   PubMed=10049729; DOI=10.1006/bbrc.1999.0176;
RA   Mechref Y., Ma W., Hao G., Novotny M.V.;
RT   "N-linked oligosaccharides of vomeromodulin, a putative pheromone
RT   transporter in rat.";
RL   Biochem. Biophys. Res. Commun. 255:451-455(1999).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1752363}.
CC   -!- TISSUE SPECIFICITY: Abundant in the lateral nasal glands
CC       (PubMed:1915264, PubMed:1752363). Also present in the posterior septal
CC       and vomeronasal glands (PubMed:1752363). {ECO:0000269|PubMed:1752363,
CC       ECO:0000269|PubMed:1915264}.
CC   -!- PTM: N-glycosylated (PubMed:1752363, PubMed:10049729). The N-glycans
CC       consist mainly of complex sialylated and fucosylated biantennary
CC       structures (PubMed:10049729). {ECO:0000269|PubMed:10049729,
CC       ECO:0000269|PubMed:1752363}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA43066.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAA43066.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X60659; CAA43066.1; ALT_SEQ; mRNA.
DR   EMBL; X63911; CAA45366.1; -; mRNA.
DR   PIR; S23808; S23808.
DR   AlphaFoldDB; Q63751; -.
DR   STRING; 10116.ENSRNOP00000065522; -.
DR   GlyConnect; 626; 3 N-Linked glycans.
DR   GlyGen; Q63751; 3 sites, 5 N-linked glycans (1 site).
DR   PaxDb; Q63751; -.
DR   UCSC; RGD:1594746; rat.
DR   RGD; 1594746; LOC690507.
DR   eggNOG; ENOG502TKQD; Eukaryota.
DR   PRO; PR:Q63751; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:InterPro.
DR   InterPro; IPR034433; Vomeromodulin.
DR   PANTHER; PTHR40142; PTHR40142; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..589
FT                   /note="Vomeromodulin"
FT                   /id="PRO_0000065878"
FT   REGION          49..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        419
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        437
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        510
FT                   /note="S -> C (in Ref. 1; CAA43066)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   589 AA;  62793 MW;  CABA02EAE0E8F9D9 CRC64;
     MWVLQALAIM LSIQAGVLDL VEVPPVVRSL PVALPAPVNL PAVLPGSPGL NDPAKNRMLP
     PKRPGAPSRG GKCAPAARYF LSSDKLQAYL LSILPPQIED MVKCDKVNME GVLGDILATM
     QDSNLLSILD ITSLLQGGGG LGLGGLLGKE GNEDPSKPSS GSKATGGLGQ LLPEGLPGKE
     GLGGLLNLGG GKGSGKGLLN GDGLSNVVKP LDDIVENVDS LKAAVQDKVK SVVPENIKDP
     FSDLLNMDIQ ETMLKLKVKQ VKVGSTDINM GADGIKVLSE VTADVEGEGL LGPVFTLLQF
     QSVMDVTMNI AVSSNNTQCV NLDVQDTHMH VKEMNIQLLQ TVTETVPLPT SLPLNDIIPI
     VLTAKMNENL EKSDSCGIVL SDFNDCKNTT GLFGYQVHTA RISPKGLSID YCVKANIDNK
     TVPVPGGRLP PDPKNANVSI TTASSALRTL VKYVAKQSSV QMNDLEAQIT YIAFAPQENN
     MLRLLYKVDI TKDSQPYATG ETKLFISHAS KILNSKLVPD VKLTRSEHSV VPPETKEEVE
     GIMAEVTRKA WSRFNELYKK MSIPDGVSSN TLTNSDVKLL RSNDLQAAS