VOPP1_BOVIN
ID VOPP1_BOVIN Reviewed; 172 AA.
AC A6QNZ8; Q58D61;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Vesicular, overexpressed in cancer, prosurvival protein 1;
DE AltName: Full=EGFR-coamplified and overexpressed protein;
DE Short=ECop;
DE Flags: Precursor;
GN Name=VOPP1; Synonyms=ECOP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Basal ganglia;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Increases the transcriptional activity of NFKB1 by
CC facilitating its nuclear translocation, DNA-binding and associated
CC apoptotic response, when overexpressed. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}. Note=When
CC overexpressed, localizes in the nucleus and perinuclear regions.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the VOPP1/ECOP family. {ECO:0000305}.
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DR EMBL; BT021736; AAX46583.1; -; mRNA.
DR EMBL; BC149078; AAI49079.1; -; mRNA.
DR RefSeq; NP_001070440.1; NM_001076972.1.
DR AlphaFoldDB; A6QNZ8; -.
DR STRING; 9913.ENSBTAP00000016016; -.
DR PaxDb; A6QNZ8; -.
DR Ensembl; ENSBTAT00000016016; ENSBTAP00000016016; ENSBTAG00000012073.
DR GeneID; 767861; -.
DR KEGG; bta:767861; -.
DR CTD; 81552; -.
DR VEuPathDB; HostDB:ENSBTAG00000012073; -.
DR VGNC; VGNC:49588; VOPP1.
DR eggNOG; ENOG502RYIF; Eukaryota.
DR GeneTree; ENSGT00390000015821; -.
DR HOGENOM; CLU_1694909_0_0_1; -.
DR InParanoid; A6QNZ8; -.
DR OMA; VECIEAK; -.
DR OrthoDB; 1420258at2759; -.
DR TreeFam; TF332098; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000012073; Expressed in retina and 106 other tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0031301; C:integral component of organelle membrane; ISS:UniProtKB.
DR InterPro; IPR026229; VOPP1.
DR PANTHER; PTHR14971; PTHR14971; 1.
DR PRINTS; PR02068; VOPPROTEIN1.
PE 2: Evidence at transcript level;
KW Cytoplasmic vesicle; Membrane; Reference proteome; Signal; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..172
FT /note="Vesicular, overexpressed in cancer, prosurvival
FT protein 1"
FT /id="PRO_0000325916"
FT TOPO_DOM 23..60
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 142..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 150
FT /note="A -> G (in Ref. 1; AAX46583)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 172 AA; 19357 MW; B10A9C191A8A066D CRC64;
MDSLAWRVAA LLLGLLVECT EAKKHCWYFE GLYPTYYICR PYEDCCGSRC CVRALSIQRL
WYFWFLLMMG VLFCCGAGFF IRRRMYPPPL IEEPAFNVSY TRQPQNPTPG AQPLGLPYYT
DPGGSGMNPA GNPVAMAFQV QPNSSQGSTA YPPPPSYCNT PPPPYEQVVK TK
