VOPP1_MOUSE
ID VOPP1_MOUSE Reviewed; 172 AA.
AC Q8R1C3; Q3TZ79; Q8C0B7;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Vesicular, overexpressed in cancer, prosurvival protein 1;
DE AltName: Full=EGFR-coamplified and overexpressed protein;
DE Short=ECop;
DE Flags: Precursor;
GN Name=Vopp1; Synonyms=Ecop;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Inner ear, Medulla oblongata, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Increases the transcriptional activity of NFKB1 by
CC facilitating its nuclear translocation, DNA-binding and associated
CC apoptotic response, when overexpressed. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}. Note=When
CC overexpressed, localizes in the nucleus and perinuclear regions.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8R1C3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R1C3-2; Sequence=VSP_032478, VSP_032479;
CC -!- SIMILARITY: Belongs to the VOPP1/ECOP family. {ECO:0000305}.
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DR EMBL; AK030975; BAC27198.1; -; mRNA.
DR EMBL; AK031812; BAC27562.1; -; mRNA.
DR EMBL; AK158041; BAE34331.1; -; mRNA.
DR EMBL; AK170152; BAE41599.1; -; mRNA.
DR EMBL; AK170832; BAE42060.1; -; mRNA.
DR EMBL; BC024822; AAH24822.1; -; mRNA.
DR CCDS; CCDS39497.1; -. [Q8R1C3-1]
DR RefSeq; NP_666280.1; NM_146168.1. [Q8R1C3-1]
DR AlphaFoldDB; Q8R1C3; -.
DR STRING; 10090.ENSMUSP00000109936; -.
DR PhosphoSitePlus; Q8R1C3; -.
DR PaxDb; Q8R1C3; -.
DR PRIDE; Q8R1C3; -.
DR ProteomicsDB; 300175; -. [Q8R1C3-1]
DR ProteomicsDB; 300176; -. [Q8R1C3-2]
DR Antibodypedia; 27923; 132 antibodies from 20 providers.
DR DNASU; 232023; -.
DR Ensembl; ENSMUST00000114297; ENSMUSP00000109936; ENSMUSG00000037788. [Q8R1C3-1]
DR Ensembl; ENSMUST00000127485; ENSMUSP00000115377; ENSMUSG00000037788. [Q8R1C3-2]
DR GeneID; 232023; -.
DR KEGG; mmu:232023; -.
DR UCSC; uc009cco.1; mouse. [Q8R1C3-1]
DR CTD; 81552; -.
DR MGI; MGI:2141658; Vopp1.
DR VEuPathDB; HostDB:ENSMUSG00000037788; -.
DR eggNOG; ENOG502RYIF; Eukaryota.
DR GeneTree; ENSGT00390000015821; -.
DR HOGENOM; CLU_2120306_0_0_1; -.
DR InParanoid; Q8R1C3; -.
DR OMA; KYTITHT; -.
DR OrthoDB; 1420258at2759; -.
DR PhylomeDB; Q8R1C3; -.
DR TreeFam; TF332098; -.
DR BioGRID-ORCS; 232023; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Vopp1; mouse.
DR PRO; PR:Q8R1C3; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8R1C3; protein.
DR Bgee; ENSMUSG00000037788; Expressed in retinal neural layer and 261 other tissues.
DR ExpressionAtlas; Q8R1C3; baseline and differential.
DR Genevisible; Q8R1C3; MM.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; ISO:MGI.
DR GO; GO:0031301; C:integral component of organelle membrane; ISS:UniProtKB.
DR InterPro; IPR026229; VOPP1.
DR PANTHER; PTHR14971; PTHR14971; 1.
DR PRINTS; PR02068; VOPPROTEIN1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasmic vesicle; Membrane; Reference proteome;
KW Signal; Transcription; Transcription regulation; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..172
FT /note="Vesicular, overexpressed in cancer, prosurvival
FT protein 1"
FT /id="PRO_0000325918"
FT TOPO_DOM 23..60
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..172
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 139..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..162
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 110..114
FT /note="GAQQM -> ELTDS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032478"
FT VAR_SEQ 115..172
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032479"
FT CONFLICT 40
FT /note="R -> H (in Ref. 1; BAC27562)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 172 AA; 19424 MW; F2C7CAC154805A03 CRC64;
MGRRLGRVAA LLLGLLVECT EAKKHCWYFE GLYPTYYICR SYEDCCGSRC CVRALSIQRL
WYFWFLLMMG VLFCCGAGFF IRRRMYPPPL IEEPTFNVSY TRQPPNPAPG AQQMGPPYYT
DPGGPGMNPV GNTMAMAFQV QPNSPHGGTT YPPPPSYCNT PPPPYEQVVK DK
