ID   VOPP1_PONAB             Reviewed;         172 AA.
AC   Q5RDG5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Vesicular, overexpressed in cancer, prosurvival protein 1;
DE   AltName: Full=EGFR-coamplified and overexpressed protein;
DE            Short=ECop;
DE   Flags: Precursor;
GN   Name=VOPP1; Synonyms=ECOP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Increases the transcriptional activity of NFKB1 by
CC       facilitating its nuclear translocation, DNA-binding and associated
CC       apoptotic response, when overexpressed. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}. Note=When
CC       overexpressed, localizes in the nucleus and perinuclear regions.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VOPP1/ECOP family. {ECO:0000305}.
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DR   EMBL; CR857945; CAH90192.1; -; mRNA.
DR   RefSeq; NP_001125072.1; NM_001131600.1.
DR   AlphaFoldDB; Q5RDG5; -.
DR   STRING; 9601.ENSPPYP00000020477; -.
DR   Ensembl; ENSPPYT00000061006; ENSPPYP00000025243; ENSPPYG00000018284.
DR   GeneID; 100171953; -.
DR   KEGG; pon:100171953; -.
DR   CTD; 81552; -.
DR   eggNOG; ENOG502RYIF; Eukaryota.
DR   GeneTree; ENSGT00390000015821; -.
DR   HOGENOM; CLU_1694909_0_0_1; -.
DR   InParanoid; Q5RDG5; -.
DR   OMA; VECIEAK; -.
DR   OrthoDB; 1420258at2759; -.
DR   TreeFam; TF332098; -.
DR   Proteomes; UP000001595; Chromosome 7.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0031301; C:integral component of organelle membrane; ISS:UniProtKB.
DR   InterPro; IPR026229; VOPP1.
DR   PANTHER; PTHR14971; PTHR14971; 1.
DR   PRINTS; PR02068; VOPPROTEIN1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Membrane; Reference proteome; Signal; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..172
FT                   /note="Vesicular, overexpressed in cancer, prosurvival
FT                   protein 1"
FT                   /id="PRO_0000325919"
FT   TOPO_DOM        23..60
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        82..172
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          102..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..123
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  19239 MW;  6BC03EC31C2A4276 CRC64;
     MRRQPAKVAA LLLGLLLECT EAKKHCWYFE GLYPTYYICR SYEDCCGSRC CVRALSIQRL
     WYFWFLLMMG VLFCCGAGFF IRRRMYPPPL IEEPAFNVSY TRQPPNPGPG AQQPGPPYYT
     DPGGPGMNPV GNSMAMAFQL PPNSPQGSVA CPPPPAYCNT PPPPYEQVVK AK