ID   VOPP1_XENLA             Reviewed;         168 AA.
AC   Q5XGS4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Vesicular, overexpressed in cancer, prosurvival protein 1;
DE   AltName: Full=EGFR-coamplified and overexpressed protein homolog;
DE            Short=ECop;
DE   Flags: Precursor;
GN   Name=vopp1; Synonyms=ecop;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the transcriptional activity of NFKB1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VOPP1/ECOP family. {ECO:0000305}.
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DR   EMBL; BC084358; AAH84358.1; -; mRNA.
DR   RefSeq; NP_001088316.1; NM_001094847.1.
DR   AlphaFoldDB; Q5XGS4; -.
DR   DNASU; 495153; -.
DR   GeneID; 495153; -.
DR   KEGG; xla:495153; -.
DR   CTD; 495153; -.
DR   Xenbase; XB-GENE-5807306; vopp1.S.
DR   OMA; WIFLEIL; -.
DR   OrthoDB; 1420258at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 495153; Expressed in brain and 15 other tissues.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0031301; C:integral component of organelle membrane; ISS:UniProtKB.
DR   InterPro; IPR026229; VOPP1.
DR   PANTHER; PTHR14971; PTHR14971; 1.
DR   PRINTS; PR02068; VOPPROTEIN1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Membrane; Reference proteome; Signal; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..168
FT                   /note="Vesicular, overexpressed in cancer, prosurvival
FT                   protein 1"
FT                   /id="PRO_0000325920"
FT   TOPO_DOM        22..59
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..168
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          130..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..157
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   168 AA;  19155 MW;  DE58E5071D993EED CRC64;
     MKSLHCVGLY LLSLLCQLTE AKKHCWYFEG LYPTYYICRA YEDCCGSRCC VRALSIQRLW
     YFWFLLMMGV LFCCGAGFFI RRRMYPPLLV DEPTFNVSYT RQPAGPPGGP QQPVMPYYSD
     PGGAMGNPMT PSFYVQPNSP QGNPPFPPPP SYCNTPPPPY EQVVKSYK