ID   VOPP1_XENTR             Reviewed;         167 AA.
AC   Q0V9A8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Vesicular, overexpressed in cancer, prosurvival protein 1;
DE   AltName: Full=EGFR-coamplified and overexpressed protein homolog;
DE            Short=ECop;
DE   Flags: Precursor;
GN   Name=vopp1; Synonyms=ecop;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Stomach;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in the transcriptional activity of NFKB1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VOPP1/ECOP family. {ECO:0000305}.
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DR   EMBL; BC121667; AAI21668.1; -; mRNA.
DR   RefSeq; NP_001072426.1; NM_001078958.1.
DR   AlphaFoldDB; Q0V9A8; -.
DR   STRING; 8364.ENSXETP00000057511; -.
DR   PaxDb; Q0V9A8; -.
DR   DNASU; 779880; -.
DR   Ensembl; ENSXETT00000057511; ENSXETP00000057511; ENSXETG00000027607.
DR   GeneID; 779880; -.
DR   KEGG; xtr:779880; -.
DR   CTD; 81552; -.
DR   Xenbase; XB-GENE-5807279; vopp1.
DR   eggNOG; ENOG502RYIF; Eukaryota.
DR   HOGENOM; CLU_1694909_0_0_1; -.
DR   InParanoid; Q0V9A8; -.
DR   OMA; WIFLEIL; -.
DR   OrthoDB; 1420258at2759; -.
DR   TreeFam; TF332098; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000027607; Expressed in brain and 13 other tissues.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0031301; C:integral component of organelle membrane; ISS:UniProtKB.
DR   InterPro; IPR026229; VOPP1.
DR   PANTHER; PTHR14971; PTHR14971; 1.
DR   PRINTS; PR02068; VOPPROTEIN1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Membrane; Reference proteome; Signal; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..167
FT                   /note="Vesicular, overexpressed in cancer, prosurvival
FT                   protein 1"
FT                   /id="PRO_0000325921"
FT   TOPO_DOM        22..59
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..167
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          101..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..156
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   167 AA;  18965 MW;  87F232501BE7B4DA CRC64;
     MKSLHCVGLY LLSLLCEFTE AKKHCWYFEG LYPTYYICRA YEDCCGSRCC VRALSIQRLW
     YFWFLLMMGV LFCCGAGFFI RRRMYPPLLV DEPTFNVSYT RQPAGPPPGP QHPGMPYYSD
     PGGAMGNPVT PSFHVQPSPQ GNPPFPPPPS YCNTPPPPYE QVVKSCK