ID   VORA_METTM              Reviewed;         478 AA.
AC   P80907; D9PWT8; D9PWT9;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Ketoisovalerate oxidoreductase subunit VorA;
DE            Short=VOR;
DE            EC=1.-.-.-;
DE   AltName: Full=2-oxoisovalerate oxidoreductase alpha chain;
DE   AltName: Full=2-oxoisovalerate-ferredoxin oxidoreductase subunit alpha;
GN   Name=vorA; OrderedLocusNames=MTBMA_c10920/MTBMA_c10930;
OS   Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM
OS   14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium
OS   thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=79929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=20802048; DOI=10.1128/jb.00844-10;
RA   Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H.,
RA   Gottschalk G., Thauer R.K.;
RT   "Complete genome sequence of Methanothermobacter marburgensis, a
RT   methanoarchaeon model organism.";
RL   J. Bacteriol. 192:5850-5851(2010).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-16, BIOPHYSICOCHEMICAL PROPERTIES, AND SUBUNIT.
RC   STRAIN=ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 /
RC   Marburg;
RX   PubMed=9108258; DOI=10.1111/j.1432-1033.1997.00862.x;
RA   Tersteegen A., Linder D., Thauer R.K., Hedderich R.;
RT   "Structures and functions of four anabolic 2-oxoacid oxidoreductases in
RT   Methanobacterium thermoautotrophicum.";
RL   Eur. J. Biochem. 244:862-868(1997).
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Optimum pH is 9.7. {ECO:0000269|PubMed:9108258};
CC       Temperature dependence:
CC         Optimum temperature is 75 degrees Celsius.
CC         {ECO:0000269|PubMed:9108258};
CC   -!- SUBUNIT: Heterotrimer of the VorA, VorB and VorC subunits.
CC       {ECO:0000269|PubMed:9108258}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ADL58686.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=ADL58687.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP001710; ADL58686.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP001710; ADL58687.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P80907; -.
DR   SMR; P80907; -.
DR   STRING; 79929.MTBMA_c10930; -.
DR   EnsemblBacteria; ADL58686; ADL58686; MTBMA_c10920.
DR   EnsemblBacteria; ADL58687; ADL58687; MTBMA_c10930.
DR   KEGG; mmg:MTBMA_c10920; -.
DR   KEGG; mmg:MTBMA_c10930; -.
DR   PATRIC; fig|79929.8.peg.1070; -.
DR   HOGENOM; CLU_2392937_0_0_2; -.
DR   Proteomes; UP000000345; Chromosome.
DR   GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.920.10; -; 1.
DR   InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR   InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme-bd_C.
DR   Pfam; PF01558; POR; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
DR   SUPFAM; SSF53323; SSF53323; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Oxidoreductase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:9108258"
FT   CHAIN           2..478
FT                   /note="Ketoisovalerate oxidoreductase subunit VorA"
FT                   /id="PRO_0000099950"
SQ   SEQUENCE   478 AA;  51879 MW;  24648E79105E8964 CRC64;
     MTKKVIRKPD SLHEVFERKG GSAPTATHYC AGCGHGILHK LIGEAIDELG IQERSVMISP
     VGCAVFAYYY FDCGNVQVAH GRAPAVGTGI SRAEDTPVVL LYQGDGDLAS IGLNETIQAA
     NRGEKMAVFF VNNTVYGMTG GQMAPTTLIG EVTVTCPGGR DPRYAGYPLH MCELLDNLQA
     PVFIERVSLA DPKSIRKAKR AVKRALEIQR DGKGYAFVEV LSPCPTNLRQ DAEGAERFLK
     EEMEREFPVK NFRDRSSETE PLIRSESDFS RESLDRIFQI KEDSVPDPVD DPEFREVRVK
     IAGFGGQGVL SMGLTLAQAA CSEGRHTSWY PAYGPEQRGG TSSCGVVISG ERVGSPAVDT
     PDVLVAFNQP SLDEFAGDVR EGGIVLYDTA TADFSKKENL RAIGVPALEI AKEHGTGRAA
     NTAMLGVMMA LGITGLDEES FRDAIRFTFS GKDKIIDINL KILEAGADWA RKNLEGEF