VOSA_COCH5
ID VOSA_COCH5 Reviewed; 350 AA.
AC M2U3Z7;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 16-MAR-2016, sequence version 2.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Spore development regulator vosA {ECO:0000305};
GN Name=VOS1 {ECO:0000303|PubMed:25080135}; ORFNames=COCHEDRAFT_1067256;
OS Cochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern
OS corn leaf blight fungus) (Bipolaris maydis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=701091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O;
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 / ATCC 48332 / race O;
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
RN [3]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX PubMed=25080135; DOI=10.1016/j.fgb.2014.07.010;
RA Wang W., Wu D., Pan H., Turgeon B.G.;
RT "Vel2 and Vos1 hold essential roles in ascospore and asexual spore
RT development of the heterothallic maize pathogen Cochliobolus
RT heterostrophus.";
RL Fungal Genet. Biol. 70:113-124(2014).
CC -!- FUNCTION: Component of the VEL2-VOS1 heterodimeric complex that plays a
CC dual role in activating genes associated with spore maturation and
CC repressing certain development-associated genes (By similarity). The
CC complex binds DNA through the DNA-binding domain of VOS1 that
CC recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC consisting of two motifs in the promoters of key developmental
CC regulatory genes (By similarity). Required for normal pseudothecium
CC development and regulates asexual spore compartmentalization,
CC pigmentation and germination (PubMed:25080135).
CC {ECO:0000250|UniProtKB:Q5BBX1, ECO:0000269|PubMed:25080135}.
CC -!- SUBUNIT: Forms a heterodimeric complex with VEL2; the formation of the
CC VEL2-VOS1 complex is light-dependent (By similarity).
CC {ECO:0000250|UniProtKB:Q5BBX1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5BBX1}.
CC -!- INDUCTION: Expression is negatively regulated by VEL1
CC (PubMed:25080135). {ECO:0000269|PubMed:25080135}.
CC -!- DOMAIN: The N-terminal velvet domain contains a NF-kappa-B-like fold
CC and is involved in DNA-binding (By similarity).
CC {ECO:0000250|UniProtKB:Q5BBX1}.
CC -!- DISRUPTION PHENOTYPE: Produces only albino pseudothecia
CC (PubMed:25080135). Reduces tolerance to oxidative and thermal stresses
CC (PubMed:25080135). {ECO:0000269|PubMed:25080135}.
CC -!- SIMILARITY: Belongs to the velvet family. VosA subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EMD93264.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB445573; EMD93264.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; M2U3Z7; -.
DR SMR; M2U3Z7; -.
DR STRING; 701091.M2U3Z7; -.
DR EnsemblFungi; EMD93264; EMD93264; COCHEDRAFT_1067256.
DR eggNOG; ENOG502RYQD; Eukaryota.
DR HOGENOM; CLU_1286061_0_0_1; -.
DR Proteomes; UP000016936; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 1.
DR Pfam; PF11754; Velvet; 2.
DR PROSITE; PS51821; VELVET; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..350
FT /note="Spore development regulator vosA"
FT /id="PRO_0000435789"
FT DOMAIN 46..244
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 250..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 274..281
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:M2TGT8"
FT COMPBIAS 253..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 350 AA; 39473 MW; 9783CA90F6A84172 CRC64;
MAFTYNYSLQ ASYPSQRAYV PYQQAQVPTP SPIYSLPITN TTTAGALSPS SCFLSVRQQP
KEALVTVKGK EKFRKPLDPP PMLELKVSSE IDPSQQFLQN PYLFVSVSLY KHDKDEAIEG
TPFDILAGTL VSSLHRLKDV NNKDGAFFIF GDISIKVQGT YRLRFTLYEL QPSYFTLSDL
EQHKDLERYQ GAALDPPEYG TYQCLGHVLS DKFNVVLPKD FKGLEESTYL SRAFSDQGVR
LRLRKEARGM MSNKRSISGS GDLTTDQSQQ QQQQQQPLAK KRREDSVESA NPSSLMSGFY
QNVSPFVNTP YLQTQGLQPQ NLQNQGLQTP VRHDANYAWN LAYDPSFMGS
