VOSA_COCSN
ID VOSA_COCSN Reviewed; 348 AA.
AC M2TGT8;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 16-MAR-2016, sequence version 2.
DT 25-MAY-2022, entry version 33.
DE RecName: Full=Spore development regulator vosA {ECO:0000305};
GN Name=vosA {ECO:0000303|PubMed:26399184}; ORFNames=COCSADRAFT_62627;
OS Cochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and
OS spot blotch fungus) (Bipolaris sorokiniana).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae; Bipolaris.
OX NCBI_TaxID=665912;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652;
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ND90Pr / ATCC 201652;
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
RN [3]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX PubMed=26399184; DOI=10.1016/j.funbio.2015.06.009;
RA Wang R., Leng Y., Zhong S.;
RT "The regulatory gene VosA affects conidiogenesis and is involved in
RT virulence of the fungal cereal pathogen Cochliobolus sativus.";
RL Fungal Biol. 119:884-900(2015).
CC -!- FUNCTION: Component of the velB-VosA heterodimeric complex that plays a
CC dual role in activating genes associated with spore maturation and
CC repressing certain development-associated genes (By similarity). The
CC complex binds DNA through the DNA-binding domain of vosA that
CC recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC consisting of two motifs in the promoters of key developmental
CC regulatory genes (By similarity). Regulates spore viability, trehalose
CC accumulation, and tolerance to thermal and oxidative as well as ion
CC stresses (PubMed:26399184). Positively regulates conidial pigmentation
CC and pathogenicity on barley (PubMed:26399184).
CC {ECO:0000250|UniProtKB:Q5BBX1, ECO:0000269|PubMed:26399184}.
CC -!- SUBUNIT: Forms a heterodimeric complex with VEL2; the formation of the
CC VEL2-VOS1 complex is light-dependent (By similarity).
CC {ECO:0000250|UniProtKB:Q5BBX1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5BBX1}.
CC -!- INDUCTION: Expression is up-regulated in conidia (PubMed:26399184).
CC {ECO:0000269|PubMed:26399184}.
CC -!- DOMAIN: The N-terminal velvet domain contains a NF-kappa-B-like fold
CC and is involved in DNA-binding (By similarity).
CC {ECO:0000250|UniProtKB:Q5BBX1}.
CC -!- DISRUPTION PHENOTYPE: Reduces the amount of thehalose in conidia,
CC tolerance to heat, oxidative and osmotic stress (PubMed:26399184).
CC {ECO:0000269|PubMed:26399184}.
CC -!- SIMILARITY: Belongs to the velvet family. VosA subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EMD67942.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; KB445638; EMD67942.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_007695649.1; XM_007697459.1.
DR AlphaFoldDB; M2TGT8; -.
DR SMR; M2TGT8; -.
DR STRING; 665912.M2TGT8; -.
DR EnsemblFungi; EMD67942; EMD67942; COCSADRAFT_62627.
DR GeneID; 19140401; -.
DR KEGG; bsc:COCSADRAFT_62627; -.
DR eggNOG; ENOG502RYQD; Eukaryota.
DR HOGENOM; CLU_1286061_0_0_1; -.
DR OrthoDB; 1407766at2759; -.
DR PHI-base; PHI:5104; -.
DR Proteomes; UP000016934; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 1.
DR Pfam; PF11754; Velvet; 2.
DR PROSITE; PS51821; VELVET; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..348
FT /note="Spore development regulator vosA"
FT /id="PRO_0000435788"
FT DOMAIN 46..244
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 250..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 274..280
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000305|PubMed:26399184"
FT COMPBIAS 253..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 39180 MW; BB951B517124316C CRC64;
MAFSYNYSLQ ASYPSQRAYV PYQQTQVPTP SPIYSLPITN TTTSGALSPS SCFLSVRQQP
KEALVTVKGK EKFRKPLDPP PMLELKVSSD IDPSQQFLQN PYLFVSVSLY KHDKDEPIEG
TPFDVLAGTL VSSLHRLKDV NNKDGAFFIF GDISIKVQGT YRLRFTLYEL QPSYFTLSDL
EQHKDLERYQ GAALDPPEYG TYQCLGHVLS DKFNVVLPKD FKGLEESTYL SRAFSDQGVR
LRLRKEARGM MSNKRSISGS GDLTSDQSQQ QQQQQPLAKK RREDSVESAN PSSLMSGFYQ
NVSPFVNTPY LQSQGLQGQT LQNQGLQAPV RHDTSYAWNL AYDPSFMG
