VOSA_PENRW
ID VOSA_PENRW Reviewed; 390 AA.
AC B6HQ74;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Spore development regulator vosA {ECO:0000305};
GN Name=vosA {ECO:0000303|PubMed:23264641};
GN ORFNames=Pc22g06890, PCH_Pc22g06890;
OS Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS 54-1255) (Penicillium chrysogenum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC Penicillium chrysogenum species complex.
OX NCBI_TaxID=500485;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX PubMed=18820685; DOI=10.1038/nbt.1498;
RA van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA Bovenberg R.A.L.;
RT "Genome sequencing and analysis of the filamentous fungus Penicillium
RT chrysogenum.";
RL Nat. Biotechnol. 26:1161-1168(2008).
RN [2]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBCELLULAR LOCATION, AND INTERACTION WITH
RP VELA; VELB AND VELC.
RX PubMed=23264641; DOI=10.1128/ec.00272-12;
RA Kopke K., Hoff B., Bloemendal S., Katschorowski A., Kamerewerd J.,
RA Kueck U.;
RT "Members of the Penicillium chrysogenum velvet complex play functionally
RT opposing roles in the regulation of penicillin biosynthesis and
RT conidiation.";
RL Eukaryot. Cell 12:299-310(2013).
CC -!- FUNCTION: Component of the velB-VosA heterodimeric complex that plays a
CC dual role in activating genes associated with spore maturation and
CC repressing certain development-associated genes (PubMed:23264641). The
CC complex binds DNA through the DNA-binding domain of vosA that
CC recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3'
CC consisting of two motifs in the promoters of key developmental
CC regulatory genes (By similarity). {ECO:0000250|UniProtKB:Q5BBX1,
CC ECO:0000269|PubMed:23264641}.
CC -!- SUBUNIT: Forms a heterodimeric complex with velB; the formation of the
CC velB-vosA complex is light-dependent (By similarity). Interacts with
CC velA, velB and velC (PubMed:23264641). {ECO:0000250|UniProtKB:Q5BBX1,
CC ECO:0000269|PubMed:23264641}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23264641}.
CC -!- DOMAIN: The N-terminal velvet domain contains a NF-kappa-B-like fold
CC and is involved in DNA-binding (By similarity).
CC {ECO:0000250|UniProtKB:Q5BBX1}.
CC -!- DISRUPTION PHENOTYPE: Results in a severe conidiation defect with
CC reduced sporulation (PubMed:23264641). {ECO:0000269|PubMed:23264641}.
CC -!- SIMILARITY: Belongs to the velvet family. VosA subfamily.
CC {ECO:0000305}.
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DR EMBL; AM920437; CAP97977.1; -; Genomic_DNA.
DR RefSeq; XP_002564715.1; XM_002564669.1.
DR AlphaFoldDB; B6HQ74; -.
DR SMR; B6HQ74; -.
DR STRING; 1108849.XP_002564715.1; -.
DR EnsemblFungi; CAP97977; CAP97977; PCH_Pc22g06890.
DR GeneID; 8305813; -.
DR KEGG; pcs:Pc22g06890; -.
DR VEuPathDB; FungiDB:PCH_Pc22g06890; -.
DR eggNOG; ENOG502RYQD; Eukaryota.
DR HOGENOM; CLU_034766_1_0_1; -.
DR OMA; CCSLYDA; -.
DR OrthoDB; 1407766at2759; -.
DR BioCyc; PCHR:PC22G06890-MON; -.
DR Proteomes; UP000000724; Contig Pc00c22.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.3960; -; 1.
DR InterPro; IPR021740; Velvet.
DR InterPro; IPR037525; Velvet_dom.
DR InterPro; IPR038491; Velvet_dom_sf.
DR PANTHER; PTHR33572; PTHR33572; 2.
DR Pfam; PF11754; Velvet; 1.
DR PROSITE; PS51821; VELVET; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..390
FT /note="Spore development regulator vosA"
FT /id="PRO_0000435915"
FT DOMAIN 3..132
FT /note="Velvet"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01165"
FT REGION 137..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 273..280
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250|UniProtKB:M2TGT8"
FT COMPBIAS 137..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 390 AA; 42821 MW; FE56D80F694A50B8 CRC64;
MLNNTSSDFD LIIRQQPNRA RVAGGKEKEE RPVPVAPSTA LAGTLVSSLH RLKDVDNSDG
GFFVFGDLSV KIEGEFRLKF TLFEMRKDRV SYLKTVISER FTVSPPKSFP GMMESTHLSR
SFADQGVKLR IRKEPRTMLK RSTRPDEFHQ PVPTRSPERQ SVQIPPSSSY GGYPPAARDY
GYYGQQPPVK RHRTSIDYGR QQGLYDVDGR MARQMDPYGQ PTAAMYAGQP AAYQTPAAMQ
TYNTGQVVPD YTAMYPGMQA SAGMQASAPM SQIPDPTGQS RSSQQQQAAV GQLMAMNQPG
TPTPDSTGAM MAQGYARSGY PPSSTILPPL QRSRDYPQGT NGSARAYFDQ TPQANTPILP
SQMVNEGDRF SSVTGPTTFN HPDSPNGTPQ
